Stimulating the liver to produce some of the signals of the thymus can reverse age-related declines in T-cell populations and enhance response to vaccination.
We are a research organization dedicated to understanding the roots of disease and closing the gap between new biological insights and impact for patients.
We are characterizing the genetic and mechanistic basis of brain health and brain diseases.
Cancer
Our scientists are probing the mechanisms of cancer and applying this knowledge to enable precision cancer medicine.
Cardiovascular disease
By applying a variety of tools and technologies, researchers here are working to reduce the burden of cardiovascular disease.
Chronic disease
By uncovering the biology underlying heart disease, diabetes, cancer, and more, we’re helping to develop effective new treatments that target the root causes of these chronic diseases.
Diabetes
Our researchers study the cellular roles and physiological impacts of genes associated with type 2 diabetes.
Infectious disease and the microbiome
Researchers across the institute are working to understand infectious diseases, antibiotic resistance, and the human microbiome.
Kidney disease
Our scientists are cataloging the molecular causes of kidney diseases in order to develop mechanism-based treatments.
Obesity
By studying the genetic determinants of body weight, our researchers work to identify targets for future obesity therapies.
Rare disease
Our scientists search for the risk factors underlying rare genetic diseases to help reveal their biological underpinnings and improve patients' lives.
Members of the Data Sciences Platform build open-source technologies that help researchers everywhere connect to the patients, datasets, and tools they need to do life-changing science.
Drug Discovery
Our Center for the Development of Therapeutics (CDoT) helps scientists advance biological insights to new treatments.
Genetic perturbation
The Genetic Perturbation Platform drives the functional study of the genome by developing groundbreaking technologies for perturbing genes at scale.
Genomics
Genomic scientists here at Ó³»´«Ã½ create foundational resources and study the genomic basis of human traits and diseases.
Imaging
Computationally mining cellular images' rich information content can propel discoveries in biology and medicine.
Metabolomics
Cells' metabolites reveal unique chemical fingerprints of both normal and pathological disease processes.
Proteomics
Ó³»´«Ã½ proteomic researchers address important questions in biology, chemistry, and clinical science through collaboration and technology development.
Spatial technologies
The Spatial Technology Platform expands the impact of spatial -omics through comprehensive support – from study design to data acquisition and processing – for a broad range of users. We also maintain an active research arm that develops and advances cutting edge spatial, imaging, and computational technologies.
Through innovative technologies, foundational resources, and breakthrough discoveries, Ó³»´«Ã½ scientists are addressing important questions in human biology, health, and disease. See how our science has evolved.
Searchable publication catalog
Search a comprehensive list of all scientific papers published by Ó³»´«Ã½ scientists over the years.