Breadcrumb Home Chembio-Therapeutics CBTS Supergroup Meetings Regular program meetings draw participants from many research communities to share cutting-edge research and brainstorm new project ideas in a wide variety of fields relevant to chemical biology and therapeutics science. If you are interested in nominating a speaker for a meeting, please contact us at CBTS-central@broadinstitute.org. 2024-2025 Speakers 12/04/2024 E3-substrate tagging by ubiquitin biotinylation Hubert Huang Sellers Lab 12/04/2024 High-Throughput in Silico Genetic Screen for Discovering Novel Genoma Regulations Bio Xia Xia Lab 11/13/2024 Spatially resolved single-cell genomics and cell atlas of the brain Meng Zhang Zhuang Lab 10/23/2024 Light-directed evolution of dynamic and multi-state proteins Sahand Rahi EPFL 10/02/2024 Covalent Stabilization of Ternary Complexes for Cell-Cell "Induced Proximity" Anthony Rullo McMaster Immunology Research Center 09/04/2024 Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms Hanjie Jiang Cole Lab 09/04/2024 Engineering tumor-specific PROTACs in MDM2-amplified cancers Sam Bevill Qi Lab 2023-2024 Speakers 03/13/2024 Hit identification using DNA-encoded library (DEL) screening and machine learning (ML) methods - DEL+ML approaches Sumaiya Iqbal & Holly Soutter CDoT 02/28/2024 Bifunctional Small Molecules That Induce Targeted Protein Relocalization and Targeted Transcriptional Regulation Will Gibson Schreiber Lab 02/28/2024 Pharmacological Targeting of the Transcription Factor - IRF4 Mike Agius Qi Lab 02/14/2024 Imaging mass spectrometry at subcellular spatial resolution with the NanoSIMS: What it can and cannot do Christelle Guillermier Cole Lab 02/14/2024 Uncoupling Histone Modification Crosstalk by Engineering Lysine Demethylase LSD1 Kwangwoon "Jon" Lee Cole Lab 01/17/2024 Shedding light on the dark matter of viral proteomes to advance our understanding of antiviral immunity Shira Weingarten-Gabbay Sabeti Lab 11/08/2023 Cell-Permeable Anti-CRISPR Proteins for Precision Genome Editing Axel Vera Raines/Choudhary Lab 11/08/2023 Gene Therapy Without the Genes: Intracellular Delivery of Therapeutic Proteins via Traceless Bioreversible Esterification Strategy Joomyung "Vicky" Jun Raines Lab 10/25/2023 Continuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues Jaron Mercer & Shourya Roy Burman Liu Lab and Fischer Lab 10/11/2023 Optogenetic polymerization of functional materials for modulation of single neuron excitability Chanan Sessler Wang Lab 10/11/2023 Targeted Degradation of Membrane Proteins: Transferrin Receptor Targeting Chimeras (TransTACs) Kaitlin Rhee Zhou Lab Past Speakers 03/13/2024 Hit identification using DNA-encoded library (DEL) screening and machine learning (ML) methods - DEL+ML approaches Sumaiya Iqbal & Holly Soutter CDoT 02/28/2024 Bifunctional Small Molecules That Induce Targeted Protein Relocalization and Targeted Transcriptional Regulation Will Gibson Schreiber Lab 02/28/2024 Pharmacological Targeting of the Transcription Factor - IRF4 Mike Agius Qi Lab 02/14/2024 Imaging mass spectrometry at subcellular spatial resolution with the NanoSIMS: What it can and cannot do Christelle Guillermier Cole Lab 02/14/2024 Uncoupling Histone Modification Crosstalk by Engineering Lysine Demethylase LSD1 Kwangwoon "Jon" Lee Cole Lab 01/17/2024 Shedding light on the dark matter of viral proteomes to advance our understanding of antiviral immunity Shira Weingarten-Gabbay Sabeti Lab 11/08/2023 Cell-Permeable Anti-CRISPR Proteins for Precision Genome Editing Axel Vera Raines/Choudhary Lab 11/08/2023 Gene Therapy Without the Genes: Intracellular Delivery of Therapeutic Proteins via Traceless Bioreversible Esterification Strategy Joomyung "Vicky" Jun Raines Lab 10/25/2023 Continuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues Jaron Mercer & Shourya Roy Burman Liu Lab and Fischer Lab 10/11/2023 Optogenetic polymerization of functional materials for modulation of single neuron excitability Chanan Sessler Wang Lab 10/11/2023 Targeted Degradation of Membrane Proteins: Transferrin Receptor Targeting Chimeras (TransTACs) Kaitlin Rhee Zhou Lab 06/21/2023 Understanding Human GeneticVariation with Precision Genome Editing Tools Alexis Komor UCSD 06/07/2023 Leveraging Dendritic Cell Lectin Engagement to Develop Effective Cancer Vaccines Valerie Lensch & Adele Gabba Kiessling Lab 05/24/2023 Functional diversification of plant small molecules by the gut microbiome tunes intestinal homeostasis Gavin Kuziel Rakoff-Nahoum Lab 04/26/2023 Flavoaffinins: a family of elusive bacterial pigments implicated in efficient anaerobic digestion of cellulose Duncan Kountz Balskus Lab 01/18/2023 Encoding chemicals and assays with DNA: Applications in Medicinal Chemistry and Biology Casey Krusemark Purdue University 12/07/2022 Schizophrenia and bipolar disorder: from human genetics towards mechanisms and therapeutics Morgan Sheng Stanley Center 11/16/2022 Structural insights into the LSD1 N-terminus using hydrogen/deuterium exchange-mass spectrometry Malvinaa Papanastasiou Proteomics Platform 11/16/2022 The LSD1 N-terminus modulates transcription factor partitioning and enhancer decommissioning Amanda Waterbury Liau Lab 11/02/2022 Designing ligand-binding proteins from scratch Nicholas Polizzi DFCI 11/02/2022 Characterizing biological electron transfer to bio-inspired polymers Alec Agee Furst Lab 10/19/2022 Designing new protein functions for proteoform editing and biosensing Xin Zhou DFCI 10/19/2022 Engineering point-of-care electrochemical diagnostics for infectious diseases​ Xingcheng "Cindy" Zhou Furst Lab 10/05/2022 Development of a bifunctional protein tag to advance targeted protein degradation research Breanne Zerfas DFCI 10/05/2022 Untargeted metabolomics reveals novel metabolic markers for T cell activation Conghui Yao Haigis Lab 09/21/2022 Smelling the glucose: Stimulating insulin secretion through olfactory receptor activation Amedeo Vetere Wagner Lab Chemical Biology and Therapeutics Science About Community Meetings and Events Ó³»´«Ã½-MIT Seminars in Chemical Biology CBTS Supergroup Meetings Funding Opportunities People Contact Us Latest news News 11.21.2024 Researchers identify source of a brain cancer’s deadly transformation News 11.20.2024 Scientists find a region of the mouse gut tightly regulated by the immune system News 11.06.2024 Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer News 11.06.2024 Study reveals how cancer immunotherapy may cause heart inflammation in some patients All news
News 11.06.2024 Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer