ࡱ> bea 1Vbjbj 4\ii],,8H\tH2zzzzU|,n  #VE_UU__zz._Fzz_06`^D0tv#v#______tv#_________, :   COLLABORATIVE HUB FOR EARLY ANTIBIOTIC DISCOVERY (CHEAD) PROJECT PROPOSAL Instructions: Application due date: May 1, 2018 Please adhere to the page restrictions indicated. Text that exceeds the restrictions will not be considered as part of the application. A complete proposal includes 1) this application form; 2) the NIH biosketch of the PI, co-investigators, and personnel working on this project; and 3) a separate file containing all chemical structures that are referenced in the proposal. Completed proposals can be emailed to  HYPERLINK "mailto:carbx@broadinstitute.org" carbx@broadinstitute.org Project Title:  FORMTEXT [Enter text here] Principal Investigator (Name, Institution, Telephone and Email)*:  FORMTEXT [Enter text here] Co-Investigators (Name, Institution, Telephone and Email)*:  FORMTEXT [Enter text here] Personnel (Name, Institution, Title (e.g., postdoc, grad student))*:  FORMTEXT [Enter text here] * Please attach the NIH biosketch of the PI, Co-investigators, and personnel working on this project. Summary (Clear, concise summary of project and its goals; less than 1/2 page):  FORMTEXT [Enter text here] Significance (Description of the importance of the therapeutic goal; less than 1/2 page):  FORMTEXT [Enter text here] Innovation (Description of the uniqueness and transforming concept highlighted by the project; less than 1 page):  FORMTEXT [Enter text here] FORMTEXT  Current Project Status (Current funding support, ongoing efforts, committed personnel and their responsibilities, and committed resources; less than 1/2 page):  FORMTEXT [Enter text here] Intellectual Property (Please describe the IP coverage of the proposed research. Note: existing IP is not a requirement for application): ID Number (Application, serial, or patent)TitleAssigneeDate FiledStatus FORMTEXT        FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT        FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT       FORMTEXT       Preliminary Data  Biological Activity (less than 2 pages):  FORMTEXT [Enter text here] Biological Assays (List the existing in vitro biological assays that are needed to evaluate the drug candidate. Identify those that currently perform as well as those you envision performing in the future, including the cell line/tissue on which compounds are tested. Organizing the assays in a flowchart is highly recommended to understand the sequence of the screening assay. Less than 1/2 page):  FORMTEXT   FORMTEXT [Enter text here] Chemical SAR (Please input all chemical structures into a separate document and submit it as a PDF file along with this completed application form. Include the source of each compound (i.e., synthesized, purchased); less than 1 page) In vivo Efficacy Model (Please indicate the existing in vivo efficacy model for your therapeutic and whether you are able to perform these studies; less than 1/2 page):  FORMTEXT [Enter text here] Translational considerations (Describe any IRB, IBC, and other approvals that have been or need to be acquired for further evaluation of drug candidates; less than 1/2 page):  FORMTEXT [Enter text here] Project Plan (89IJKWqtv|  " # ɷxiZII80jh,U h ~h.CJOJQJ^JaJ h ~hPCJOJQJ^JaJh5S5CJOJQJ^JaJhQpA5CJOJQJ^JaJht5CJOJQJ^JaJ h ~h7CJOJQJ^JaJh ~h75OJQJ^JaJh ~hSVCJOJQJaJ#h ~h B5CJOJQJ^JaJ#h ~hSV5CJOJQJ^JaJ#h ~h.5CJOJQJ^JaJ#h ~h>C5CJOJQJ^JaJ9JKY} k l m   b c / gdPgd.gd7 &dPgdPL1$7$8$H$^`Lgd. 1$7$8$H$gd7 $dNgdSV $1$7$8$H$a$gd.# P Q i j k l m z { | } ͼ}j[Ej1j'h ~hPCJOJQJaJmHnHu+jh ~hPCJOJQJUaJh ~hPCJOJQJaJ%jh ~hPCJOJQJUaJh ~h.CJOJQJaJh ~h75CJOJQJaJh ~h7CJOJQJaJ h ~hPCJOJQJ^JaJ h ~h7CJOJQJ^JaJ'jh,0JCJOJQJU^JaJ$h ~h70JCJOJQJ^JaJjh,Uh,     A B C M N O ` a b c l ѾѨѾoѾY+jh ~hPCJOJQJUaJ+j,h ~hPCJOJQJUaJh ~h7CJOJQJaJ'h ~hPCJOJQJaJmHnHu+jh ~hPCJOJQJUaJ%jh ~hPCJOJQJUaJh ~hPCJOJQJaJh ~h.CJOJQJaJh ~h.5CJOJQJaJ / 0 1 8 i k }  ͽ͉ͬwiTwAw3ihw CJOJQJ^JaJ%hPCJOJQJ^JaJmHnHu)j\hPCJOJQJU^JaJhPCJOJQJ^JaJ#jhPCJOJQJU^JaJh ~hw CJOJQJaJ&h ~h.56CJOJQJ^JaJ h ~h.CJOJQJ^JaJh ~h.5CJOJQJaJh ~h.CJOJQJaJ"h ~hP56CJOJQJaJ"h ~h.56CJOJQJaJ/ 0 1   }~4:CN$!$1$7$8$H$If^!`a$gd ~$$1$7$8$H$If]a$gd ~$$1$7$8$H$Ifa$gd ~ 1$7$8$H$gd. 1$7$8$H$gdw gdPgd. &dPgdP       & y { ̽q\I4)h ~h.B*CJOJQJ^JaJph%h ~h.B*CJOJQJaJph(h ~h.5B*CJOJQJaJph'h ~hPCJOJQJaJmHnHu+jh ~hPCJOJQJUaJh ~hPCJOJQJaJ%jh ~hPCJOJQJUaJh ~hw CJOJQJaJh ~h.CJOJQJaJ&h ~h.56CJOJQJ^JaJ h ~h.CJOJQJ^JaJ{ {bJ/J4jh ~hw B*CJOJQJUaJph.jh ~hw B*CJOJQJUaJph0h ~hPB*CJOJQJaJmHnHphu4jh ~hPB*CJOJQJUaJph%h ~hPB*CJOJQJaJph.jh ~hPB*CJOJQJUaJph%h ~hw B*CJOJQJaJph%h ~h.B*CJOJQJaJph/h ~h.56B*CJOJQJ^JaJph FHZ[]^hijϿxiVG1V+jh ~hPCJOJQJUaJh ~hPCJOJQJaJ%jh ~hPCJOJQJUaJh ~hw CJOJQJaJ&h ~h.56CJOJQJ^JaJ h ~h.CJOJQJ^JaJ%h ~hw B*CJOJQJaJphh ~h.CJOJQJaJh ~h.5CJOJQJaJ.jh ~hw B*CJOJQJUaJph0h ~hw B*CJOJQJaJmHnHphuj{|}~Źőő|gR=R*%h ~h.B*CJOJQJaJph(h ~hD6B*CJOJQJaJph(h ~h.6B*CJOJQJaJph(h ~hP6B*CJOJQJaJph(h ~hP6B*CJOJQJaJph%h ~hPB*CJOJQJaJph(h ~h.5B*CJOJQJaJphhiB/CJOJQJaJ%h ~h.B*CJOJQJaJph%jh ~hPCJOJQJUaJ'h ~hPCJOJQJaJmHnHu349:BCMNTUVWab  &ز띖~c~F~~9jh ~hEvB*CJOJQJUaJmHnHphu4jh ~hEvB*CJOJQJUaJph.jh ~hEvB*CJOJQJUaJph h ~hEv(h ~h.5B*CJOJQJaJph%h ~h.B*CJOJQJaJph%h ~h3B*CJOJQJaJph%h ~hEvB*CJOJQJaJph(h ~hEv5B*CJOJQJaJphNUVkd($$Iflr$ "`'$  TF t0`'644 lalp2yt ~$$1$7$8$H$Ifa$gd ~V8`$1$7$8$H$Ifgd ~&(*468:NPR\^`bvxzͰ͊͝oͰ͊͝TͰ͊͝94jh ~hEvB*CJOJQJUaJph4juh ~hEvB*CJOJQJUaJph4jh ~hEvB*CJOJQJUaJph%h ~hEvB*CJOJQJaJph%h ~h.B*CJOJQJaJph9jh ~hEvB*CJOJQJUaJmHnHphu.jh ~hEvB*CJOJQJUaJph4jh ~hEvB*CJOJQJUaJph(*,.B踱螃踞hM4j8 h ~hEvB*CJOJQJUaJph4j h ~hEvB*CJOJQJUaJph4jL h ~hEvB*CJOJQJUaJph%h ~hEvB*CJOJQJaJph h ~hEv%h ~h.B*CJOJQJaJph9jh ~hEvB*CJOJQJUaJmHnHphu.jh ~hEvB*CJOJQJUaJph.$1$7$8$H$Ifgd ~kda$$Ifllr$ "`'$  TF t0`'644 lalp2ytiB/,T|$1$7$8$H$Ifgd ~BDFPRTVjlnxz|~Ͱ͊͝oͰ͝h͊MͰ͊͊4j h ~hEvB*CJOJQJUaJph h ~hEv4j$ h ~hEvB*CJOJQJUaJph%h ~hEvB*CJOJQJaJph%h ~h.B*CJOJQJaJph9jh ~hEvB*CJOJQJUaJmHnHphu.jh ~hEvB*CJOJQJUaJph4j h ~hEvB*CJOJQJUaJph|~.$1$7$8$H$Ifgd ~kd $$Iflur$ "`'$  TF t0`'644 lalp2ytiB/  46Ͱ͊͝oͰ͊͝TͰ͊͝94j]h ~hEvB*CJOJQJUaJph4j h ~hEvB*CJOJQJUaJph4jq h ~hEvB*CJOJQJUaJph%h ~hEvB*CJOJQJaJph%h ~h.B*CJOJQJaJph9jh ~hEvB*CJOJQJUaJmHnHphu.jh ~hEvB*CJOJQJUaJph4j h ~hEvB*CJOJQJUaJphF$1$7$8$H$Ifgd ~68BDFHLNPRTtv|踱~k[L=[=+"h ~hLe56CJOJQJaJh ~hLeCJOJQJaJh ~h.CJOJQJaJh ~h.5CJOJQJaJ%h ~hB*CJOJQJaJph%h ~h5SB*CJOJQJaJphh5SB*CJOJQJaJphhB*CJOJQJaJph h ~hEv%h ~h.B*CJOJQJaJph9jh ~hEvB*CJOJQJUaJmHnHphu.jh ~hEvB*CJOJQJUaJphFHJL.## 1$7$8$H$gd.kd$$Iflr$ "`'$  TF t0`'644 lalp2ytiB/LNPRT|GH23UUUUUUUUUUgd. 1$7$8$H$gd* 1$7$8$H$gda 1$7$8$H$gd.  2ZjUViuxhxXxxxxxF"h ~hLe56CJOJQJaJh ~ha6CJOJQJaJh ~ha5CJOJQJaJh ~haCJOJQJaJ'h ~hPCJOJQJaJmHnHu+jh ~hPCJOJQJUaJh ~hPCJOJQJaJ%jh ~hPCJOJQJUaJh ~hEvCJOJQJaJh ~h.CJOJQJaJh ~hLeCJOJQJaJ#$%&'(234EFHTUλΥ~oY~E~5h ~ha5CJOJQJaJ'h ~hPCJOJQJaJmHnHu+jh ~hPCJOJQJUaJh ~hPCJOJQJaJ%jh ~hPCJOJQJUaJ'h ~hCJOJQJaJmHnHu+jVh ~hEvCJOJQJUaJ%jh ~hEvCJOJQJUaJh ~hEvCJOJQJaJh ~haCJOJQJaJ&h ~ha56CJOJQJ^JaJU0123:Ihoʹzjz[zzJ9 h ~h5 CJOJQJ^JaJ h ~hLeCJOJQJ^JaJh ~hLeCJOJQJaJh ~ha6CJOJQJaJh ~haCJOJQJaJh ~ha5CJOJQJaJ"h ~ha56CJOJQJaJhiB/CJOJQJ^JaJ h ~hCJOJQJ^JaJ&h ~ha56CJOJQJ^JaJ h ~hEvCJOJQJ^JaJ h ~haCJOJQJ^JaJ_`꜋{l]lIl:h ~h5 CJOJQJaJ&h ~h*56CJOJQJ^JaJh ~hLeCJOJQJaJh ~h*CJOJQJaJh ~h*5CJOJQJaJ h ~h*CJOJQJ^JaJh ~haCJOJQJaJ+h ~hPCJOJQJ^JaJmHnHu/jdh ~hPCJOJQJU^JaJ h ~hPCJOJQJ^JaJ)jh ~hPCJOJQJU^JaJTTTUUUUU줒n]nIn]4)jh ~hPCJOJQJU^JaJ&h ~hLe56CJOJQJ^JaJ h ~h5 CJOJQJ^JaJ h ~hLeCJOJQJ^JaJU h ~h*CJOJQJ^JaJ#h ~h*5CJOJQJ^JaJh ~h*CJOJQJaJ'h ~hPCJOJQJaJmHnHu+jh ~hPCJOJQJUaJh ~hPCJOJQJaJ%jh ~hPCJOJQJUaJProvide a brief outline of your proposed project plan as it relates to the ongoing efforts detailed in the Current Project Status section above. 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