New technology puts a spatial lens on CRISPR screening
Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells.

Credit: ӳý Communications
Scientists in the Spatial Technology Platform at the ӳý develop, use, and share spatial -omics approaches, such as Perturb-FISH, that can reveal the roles of genes in various cell types and the impact of intercellular interactions on health and disease.
Funding
Funding statement: This work was supported in part by the National Institutes of Health, the Israel Science Foundation, and the Simons Foundation Autism Research Initiative.
Paper cited
Binan L, et al. . Cell. Online March 12, 2025.