/ en Tue, 05 Aug 25 11:48:45 -0400 /cdot-landing-page <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Tue, 05 Aug 2025 15:48:45 +0000 rcirceo 5559241 at /news/new-drug-triggers-rapid-cell-death-cancer-models <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Tue, 29 Oct 2024 15:11:58 +0000 kzusi@broadinstitute.org 5557691 at /news/new-protein-complex-structure-reveals-possible-ways-target-key-cancer-pathway <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Wed, 13 Jul 2022 05:04:00 +0000 aviveros@broadinstitute.org 1145591 at /how-broad-scientists-are-bridging-gap-between-biological-insights-and-new-therapies <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Wed, 16 Feb 2022 16:16:47 +0000 adicorat 1127161 at /blog/whyiscience-qa-drug-discovery-scientist-discusses-broad-institute%E2%80%99s-unique-role-drug <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Wed, 09 Jun 2021 14:00:00 +0000 adicorat 915461 at /blog/combing-through-old-drugs-find-new-ones-covid-19 <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Tue, 12 May 2020 13:48:25 +0000 Namrata Sengupta 628861 at /news/marriage-microscopy-and-machine-learning <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Mon, 13 Jan 2020 21:17:17 +0000 Corie Lok 626771 at /news/novo-ventures-and-broad-institute-mit-and-harvard-launch-drug-discovery-%E2%80%9Cgreenhouse%E2%80%9D-drive <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Tue, 19 Nov 2019 12:00:53 +0000 kzusi@broadinstitute.org 625191 at /news/molecular-traffic-jam-may-underlie-rare-kidney-disease-and-several-other-protein-misfolding <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Thu, 25 Jul 2019 15:00:54 +0000 tulrich@broadinstitute.org 571761 at /blog/whyiscience-qa-donald-raymond-solves-structures-proteins-and-supports-development-better-therapeutics <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Rose Circeo</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-08-05T11:48:45-04:00" title="Tuesday, August 5, 2025 - 11:48" class="datetime">August 5, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>CDoT landing page</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>Featured description text here</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><style type="text/css">.paragraph--type--sbs-items-categories>.field__items { display:none!important; } </style></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists are continually making new biological discoveries that have the potential to create new and transformative medicines. In some cases, industry will recognize a novel insight emerging from the ӳ����ý and successfully launch a drug discovery project; more often, biological discoveries require additional work to move them to a point where industry is willing and able to ‘take over’. The Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition. </p> <p>We are a team of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. We have participated in successful (and unsuccessful) drug discovery campaigns, and we are eager to use that experience to help ӳ����ý principal investigators (PIs) move their unique biological insights closer to becoming actual therapeutics. </p> <p>Specifically, we leverage the unique technologies and capabilities of the ӳ����ý to:</p> <ul> <li aria-level="1">Validate new therapeutic hypotheses or approaches</li> <li aria-level="1">Develop assays, tools and reagents that are necessary to launch or that can accelerate a drug discovery project </li> <li aria-level="1">Create initial chemical matter, biologics or tools that de-risk a therapeutic hypothesis in proof-of-concept experiments</li> <li aria-level="1">Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Automation Laboratory</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Compound Management</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Cellular Pharmacology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Data Sciences</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">High Content Imaging & Phenotypic Screening</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Medicinal Chemistry</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Protein Technologies</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">RABIT: Rapid Automated Binder Identification technology</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Repurposing Library (Pathway Toolbox)</a></div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--sbs-items-categories-item paragraph--view-mode--default"> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="/cdot-landing-page">Small Molecule Hit Identification</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-narrow paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>We form deep scientific collaborations with ӳ����ý faculty to ensure their biology drives the drug discovery process. By collaborating with CDoT, ӳ����ý faculty and their trainees become integral members of the team, which enriches the ӳ����ý scientific community and dramatically increases the probability of successfully advancing an idea to into a new therapeutic that can benefit patients.</p> <p> Interested in working with us or learning more, email:<br> <a href="mailto:CDoT-Collaborate@broadinstitute.org">CDoT-Collaborate@broadinstitute.org</a>.<br>  </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single items-with-tabs-single"> <div class="field field--name-field-title field--type-string field--label-hidden field__item"><h2>Expertise and capabilities</h2> </div> <div class="items-with-tabs-single__tabs"> <div class="items-with-tabs-single__tabs-links"> <a href="#tab-21296" class="items-with-tabs-single__tab" data-item=tab-21296> Automation Laboratory </a> <a href="#tab-21301" class="items-with-tabs-single__tab" data-item=tab-21301> Cellular Pharmacology </a> <a href="#tab-21311" class="items-with-tabs-single__tab" data-item=tab-21311> Compound Management </a> <a href="#tab-21316" class="items-with-tabs-single__tab" data-item=tab-21316> Data Sciences </a> <a href="#tab-21321" class="items-with-tabs-single__tab" data-item=tab-21321> High Content Imaging & Phenotypic Screening </a> <a href="#tab-21326" class="items-with-tabs-single__tab" data-item=tab-21326> Protein Technologies </a> <a href="#tab-21331" class="items-with-tabs-single__tab" data-item=tab-21331> RABIT: Rapid Automated Binder Identification technology </a> <a href="#tab-21336" class="items-with-tabs-single__tab" data-item=tab-21336> Repurposing Library (Pathway Toolbox) </a> <a href="#tab-21341" class="items-with-tabs-single__tab" data-item=tab-21341> Small Molecule Hit Identification </a> </div> </div> <div class="items-with-tabs-single__content"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21296" data-item=tab-21296> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21301" data-item=tab-21301> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21311" data-item=tab-21311> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21316" data-item=tab-21316> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21321" data-item=tab-21321> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21326" data-item=tab-21326> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21331" data-item=tab-21331> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21336" data-item=tab-21336> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--items-with-tabs-single-item items-with-tabs-single-item tab-21341" data-item=tab-21341> <div class="items-with-tabs-single-item__content"> <div class="items-with-tabs-single-item__wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Tue, 25 Jun 2019 04:00:00 +0000 Abbey Bigler 552071 at