/ en Thu, 11 Dec 25 15:44:57 -0500 /center-development-therapeutics-cdot <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Thu, 11 Dec 2025 20:44:57 +0000 mnemchuk@broadinstitute.org 485396 at /news/fda-approves-first-cancer-drug-based-broad-institute-science <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Thu, 20 Nov 2025 14:50:31 +0000 kzusi@broadinstitute.org 5559731 at /news/new-drug-triggers-rapid-cell-death-cancer-models <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Tue, 29 Oct 2024 15:11:58 +0000 kzusi@broadinstitute.org 5557691 at /news/new-protein-complex-structure-reveals-possible-ways-target-key-cancer-pathway <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Wed, 13 Jul 2022 05:04:00 +0000 aviveros@broadinstitute.org 1145591 at /how-broad-scientists-are-bridging-gap-between-biological-insights-and-new-therapies <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Wed, 16 Feb 2022 16:16:47 +0000 adicorat 1127161 at /blog/whyiscience-qa-drug-discovery-scientist-discusses-broad-institute%E2%80%99s-unique-role-drug <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Wed, 09 Jun 2021 14:00:00 +0000 adicorat 915461 at /blog/combing-through-old-drugs-find-new-ones-covid-19 <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Tue, 12 May 2020 13:48:25 +0000 Namrata Sengupta 628861 at /news/marriage-microscopy-and-machine-learning <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Mon, 13 Jan 2020 21:17:17 +0000 Corie Lok 626771 at /news/novo-ventures-and-broad-institute-mit-and-harvard-launch-drug-discovery-%E2%80%9Cgreenhouse%E2%80%9D-drive <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Tue, 19 Nov 2019 12:00:53 +0000 kzusi@broadinstitute.org 625191 at /news/molecular-traffic-jam-may-underlie-rare-kidney-disease-and-several-other-protein-misfolding <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-12-11T15:44:57-05:00" title="Thursday, December 11, 2025 - 15:44" class="datetime">December 11, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>The Center for the Development of Therapeutics (CDoT) </h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-featured-description"> <div class="clearfix text-formatted field field--name-field-gsp-featured-description field--type-text-long field--label-hidden field__item"><p>The Center for the Development of Therapeutics (CDoT) enables many aspects of the drug discovery process to help biological insights become new therapeutics.</p> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2 content-section__no-sidebars"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference-2 paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý scientists continually make new biological discoveries that have the potential to create new and transformative medicines. More often than not, these discoveries require additional work to advance them to a point where industry is willing and able to move them forward. As the ӳ����ý's drug discovery platform, the Center for the Discovery of Therapeutics (CDoT) was created to facilitate this transition.</p> <p>We are a <a href="/node/489561">team </a>of professional scientists with many years of experience working in the biotechnology and pharmaceutical industries. Collectively, we have participated in multiple drug discovery campaigns that have advanced therapeutics to human clinical trials, and we are eager to use this experience to help researchers move their unique biological insights closer to becoming actual therapeutics.</p> <p>Specifically, we leverage our unique technologies and capabilities, and those of the ӳ����ý as a whole, to:</p> <ul> <li>Validate new therapeutic hypotheses or approaches</li> <li>Develop assays, tools, and reagents that are necessary or can accelerate the launching of  a drug discovery project</li> <li>Create initial chemical matter, biologic, or tool that de-risks a therapeutic hypothesis in proof-of-concept experiments</li> <li>Scale therapeutic technologies that benefit the ӳ����ý and the greater drug discovery community</li> <li>Identify new therapeutic opportunities and help secure funding to advance ideas and technologies that benefit the ӳ����ý community</li> </ul> <p>We form deep scientific collaborations with PIs and their teams to ensure their biology drives the drug discovery process. By collaborating with CDoT, researchers and their trainees become integral members of the team, which enriches our scientific community and dramatically increases the probability of successfully advancing an idea into a new therapeutic that can benefit patients.</p> </div> </div> </div> </div> </div> </div> </div> Thu, 25 Jul 2019 15:00:54 +0000 tulrich@broadinstitute.org 571761 at