/ en Tue, 30 Sep 25 09:57:45 -0400 /news/jason-buenrostro-named-core-institute-member-broad <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Tue, 30 Sep 2025 13:57:45 +0000 Corie Lok 5559426 at /news/new-ai-based-diagnostic-tool-uses-epigenomics-accelerate-acute-leukemia-diagnosis <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Mon, 22 Sep 2025 14:00:11 +0000 tulrich@broadinstitute.org 5559416 at /news/how-massive-datasets-generated-broad-are-powering-latest-ai-models-biology <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Wed, 03 Sep 2025 18:10:36 +0000 tulrich@broadinstitute.org 5559316 at /news/whyiscience-qa-systems-biologist-uses-ai-understand-how-genome-controls-cell-fate <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Mon, 12 May 2025 13:00:00 +0000 adicorat 5558501 at /news/researchers-identify-source-brain-cancers-deadly-transformation <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Thu, 21 Nov 2024 20:34:08 +0000 Corie Lok 5557906 at /news/conversation-about-legacy-encode-and-what-comes-next-0 <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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(max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Thu, 28 Oct 2021 19:06:38 +0000 nmesa@broadinstitute.org 1126646 at /news/broad-scientists-join-new-consortium-studying-function-genetic-variation <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Thu, 28 Oct 2021 15:53:36 +0000 nmesa@broadinstitute.org 1126651 at /news/broad%E2%80%99s-new-gene-regulation-observatory-will-take-most-detailed-look-yet-non-coding-genome <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Mon, 22 Feb 2021 14:00:00 +0000 leah@broadinstitute.org 768561 at /news/epigenomic-map-reveals-circuitry-30000-human-disease-regions <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/broad_figure_nolabels-01.png?itok=TvpKWZv6 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details"><img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Mon, 08 Feb 2021 16:56:59 +0000 tulrich@broadinstitute.org 758811 at /epigenomics <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" class="datetime">September 30, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Jason Buenrostro named core institute member at ӳ����ý</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>An expert in epigenetics and longtime member of the ӳ����ý community, Buenrostro will focus on how life experiences can alter the epigenome and increase risk of disease.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By ӳ����ý Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-09-30T09:57:45-04:00" title="Tuesday, September 30, 2025 - 09:57" class="datetime">September 30, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Jason Buenrostro is standing in a lab smiling at camera."> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=oFOj5FH_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=OXq6L1-m 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=JuNYm2F1 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=DLyi8k15 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/buenrostro_2023_hi-res-download_2%20%282%29.jpg?h=2a1101da&itok=1K6WQP9o" alt="Jason Buenrostro is standing in a lab smiling at camera." title="Jason Buenrostro is standing in a lab smiling at camera." typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: John D. and Catherine T. MacArthur Foundation </div> <div class="media-caption__description"> Jason Buenrostro studies how life experiences impact health and disease. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2291/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture role="img" aria-label="Colored dots are overlaid with a greyscale microscopy image."> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/broad_figure_nolabels-01.png?itok=ANJ68x27 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/broad_figure_nolabels-01.png?itok=lA9brY_I 1x" media="all and (min-width: 1340px) and 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src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/broad_figure_nolabels-01.png?itok=E1L-yG-M" alt="Colored dots are overlaid with a greyscale microscopy image." title="Colored dots are overlaid with a greyscale microscopy image." typeof="foaf:Image"></a> </picture> </div> </article> </div> <div class="node__content"> <a href="/news/new-technique-expands-cells-sequence-dna-and-capture-fine-structural-details" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">New technique expands cells to sequence DNA and capture fine structural details</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>ӳ����ý has appointed <a href="/bios/jason-d-buenrostro">Jason Buenrostro</a> as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the <a href="/epigenomics">Epigenomics Program</a> at ӳ����ý. </p> <p>Buenrostro is a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, and has been part of the ӳ����ý community since 2016. He currently leads the <a href="/biology-of-adversity-project">Biology of Adversity Project</a> and co-leads the <a href="/gene-regulation-observatory-gro">Gene Regulation Observatory</a> at ӳ����ý. </p> <p>“Jason has been a member of the ӳ����ý for almost a decade and has made many important contributions to our community and to the epigenetics field, including technological advances routinely used by many labs,” said Todd Golub, director of the ӳ����ý. “We’re fortunate to have Jason and his lab be closely integrated with the ӳ����ý community.”  </p> <p>Buenrostro has pioneered the development of molecular tools to analyze the epigenome in single cells at scale, and has used both experimental and computational methods to reveal mechanisms of gene regulation. In 2023, he received a MacArthur Foundation Fellowship for developing methods and technologies that advance our understanding of how the cell regulates gene activity. </p> <p>As a core institute member, Buenrostro and his lab will seek to understand how cells change and adapt in response to life experiences, and how those cellular and epigenetic alterations affect health and disease.</p> <p>Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang. He was a ӳ����ý Fellow and Harvard Society Junior Fellow before joining the faculty at Harvard University and becoming an institute member at ӳ����ý.</p> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/epigenomics" hreflang="en">Epigenomics</a></div> <div class="field__item"><a href="/broad-tags/jason-buenrostro" hreflang="en">Jason Buenrostro</a></div> </div> </div> </div> </div> </div> Wed, 06 Jul 2016 16:41:34 +0000 admin 8831 at