/ en Thu, 31 Jul 25 11:55:57 -0400 /news/study-finds-biomarkers-drug-targets-risk-factors-most-common-form-lung-cancer <span class="field field--name-title field--type-string field--label-hidden"><h1>Study finds biomarkers, drug targets, risk factors for most common form of lung cancer</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-07-31T11:55:57-04:00" class="datetime">July 31, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Study finds biomarkers, drug targets, risk factors for most common form of lung cancer</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Large analysis of genes and proteins in lung adenocarcinoma points to possible new diagnostic and treatment approaches, and also reveals signatures of chemical exposures in patients who have never smoked.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Corie Lok </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-07-31T11:55:57-04:00" title="Thursday, July 31, 2025 - 11:55" class="datetime">July 31, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=GWP1xbZ_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=GWP1xbZ_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=gxIH7wLh 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=wmeltl3H 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=Q-hfwefI 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=5fL08Wv9 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=5fL08Wv9" alt="Microscopy image of lung cancer cells shown in bright colors (blue and green)" title="Microscopy image of lung cancer cells shown in bright colors (blue and green)" typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: National Cancer Institute \ Winship Cancer Institute of Emory University </div> <div class="media-caption__description"> Lung cancer cells, tagged with fluorescent proteins (green and blue), seen under a microscope. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous" /></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2476/feed&title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> 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class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/lung-cancer-proteome-builds-genetic-findings-reveal-therapeutic-strategies"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=XCehabb4 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=XCehabb4 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=iEAZOtvA 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=iEAZOtvA 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=Fr-ibLwn 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="285" height="186"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=0762cRLO 1x" media="all and (max-width: 539px)" type="image/jpeg" width="220" height="186"/> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=0762cRLO" alt="Lung cancer cells (Credit: NCI)" title="Lung cancer cells (Credit: NCI)" typeof="foaf:Image" /> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/lung-cancer-proteome-builds-genetic-findings-reveal-therapeutic-strategies" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Lung cancer proteome builds on genetic findings to reveal therapeutic strategies</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/more-complete-molecular-picture-lung-squamous-cell-carcinoma-comes-view" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/more-complete-molecular-picture-lung-squamous-cell-carcinoma-comes-view"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=3SlotK-f 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=3SlotK-f 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=2PAHGlkS 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=2PAHGlkS 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=iq3SuxmI 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="285" height="186"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=yCWwum9E 1x" media="all and (max-width: 539px)" type="image/jpeg" width="220" height="186"/> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=yCWwum9E" alt="Lung squamous cell carcinoma cells (Credit: <a href="https://flic.kr/p/efq3fp" target="_blank">Ed Uthman/Flickr</a>)" title="Lung squamous cell carcinoma cells (Credit: <a href="https://flic.kr/p/efq3fp" target="_blank">Ed Uthman/Flickr</a>)" typeof="foaf:Image" /> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/more-complete-molecular-picture-lung-squamous-cell-carcinoma-comes-view" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">A more complete molecular picture of lung squamous cell carcinoma comes into view</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never smoked. These factors include a pattern of DNA damage and signatures of exposures to chemicals found in processed foods and cosmetics. The findings could lead to better precision medicine strategies for this most common type of lung cancer. </p> <p>The researchers systematically studied genes and proteins across the whole genome and proteome in lung tumors and paired noncancerous lung tissues from more than 400 patients from North America, Eastern Europe, and Asia, making it the largest “proteogenomic” study of any cancer to date. </p> <p>By creating and studying this detailed molecular portrait of lung adenocarcinoma, the team found: </p> <ul> <li>several candidate biomarkers that could be used to more accurately identify patients with poor prognoses</li> <li>a strong link between poor outcomes and a type of DNA damage in tumors in which the DNA was broken up into many small fragments</li> <li>biological mechanisms underlying a subset of early-stage tumors that behave more like advanced cancers</li> <li>more than two dozen tumor molecules that could potentially be targeted by existing FDA-approved drugs, compounds in clinical trials, or new medicines yet to be developed. </li> </ul> <p>The work, published in <a href="https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00317-4" target="_blank"><em>Cancer Cell</em></a>, was led by scientists from the ӳ����ý, Academia Sinica in Taiwan, the University of Michigan in Ann Arbor, and other institutions, and is the result of an unprecedented collaboration between the <a href="https://dctd.cancer.gov/programs/occpr">National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC)</a> and the <a href="https://icpc.cancer.gov/portal/">International Cancer Proteogenome Consortium (ICPC)</a>, which brings together researchers from more than a dozen countries. </p> <p>Because of this collaboration, the team was able to access a large number of tumor samples and deeply analyze a range of lung cancer risk factors that haven’t been well studied before, such as exposures to chemicals beyond tobacco smoke. </p> <p>“Lung cancer continues to be the leading cancer killer worldwide, and even though we've made progress, it is not a solved problem,” said <a href="/bios/michael-gillette">Michael Gillette</a>, co-senior author of the study and senior group leader and principal investigator in the <a href="/proteomics">Proteomics Platform</a> at the ӳ����ý. “My hope is that by bringing new understanding to the biology of lung adenocarcinoma, proposing some therapeutic strategies and new ways to identify high-risk patients, and also by providing an important resource for researchers, our work will lay the groundwork for better ways to diagnose and treat this deadly cancer.”</p> <p>“Large-scale collaborations such as this one enable access to genetically and geographically varied sample sets, making this study more truly reflective of the diversity of lung adenocarcinoma," said Shankha Satpathy, co-first author of the study and a senior group leader and principal investigator in the ӳ����ý’s Proteomics Platform when the study was conducted.</p> <h2>Lung cancer atlas</h2> <p>Despite new targeted therapies for lung cancer over the last two decades, lung adenocarcinoma still kills the majority of patients, including many who have never smoked, suggesting the need for a deeper look at the disease. </p> <p>In their study, the researchers found that patients who had tumors with DNA that was shattered into many small pieces had worse prognoses. The scientists pinpointed a potential biomarker, a protein called IGF2BP3, whose levels correlated with the intensity of this genome fragmentation. The team said this candidate biomarker could potentially be used to identify patients with increased risk of severe disease.</p> <p>Because of the study’s large sample size, the scientists were able to delve into the effects of carcinogens such as tobacco smoke, air pollutants, and chemicals called nitrosamines found in processed food and cosmetics. The researchers looked for molecular signatures associated with smoking and nitrosamine exposures, and found that patients who had the strongest nitrosamine signatures were mostly never-smokers who nevertheless fared as poorly as those who had smoked. </p> <p>This surprising finding suggests that nitrosamines may be an important contributor to lung cancer risk in people who have never smoked. The team created a panel of biomarker candidates that could potentially provide prognostic signals for the disease in people with high chemical exposures. </p> <p>The scientists also learned more about a recently discovered subgroup of lung adenocarcinoma, where patients have tumors that look like early-stage disease according to conventional measures but have molecular characteristics and outcomes of late-stage cancer. The researchers revealed new details about the underlying biology fueling this “early-stage, late-like” form and suggested that these patients might benefit from closer monitoring and more intensive treatment.</p> <p>Gillette said the study shows the power of international collaboration and large-scale genomic and proteomic analysis of cancer, which may pave the way toward better clinical care. </p> <p>“The way we do prognostication now is based on clinical measures and how tumor biopsies look under a microscope,” said Gillette. “But if we can move towards using molecular signatures from tumors to determine cancer prognosis, we could do a better job of finding those early-stage cancers that will turn aggressive and treating those patients earlier and more effectively to save more lives.”    </p> <p>  <br> <em>The other first authors of the study are Natalie Clark of the ӳ����ý, Yi-Ju Chen of Academia Sinica in Taiwan, Noshad Hosseini and Yi Hsiao of University of Michigan in Ann Arbor, Ya-Hsuan Chang of National Health Research Institutes in Taiwan, Jonathan Lei of Baylor College of Medicine in Houston, Texas, Francesca Petralia of Icahn School of Medicine at Mount Sinai in New York, and Jin-Shing Chen of National Taiwan University Hospital and National Taiwan University College of Medicine. </em></p> <p><em>The study’s other senior authors are Yu-Ju Chen of Academia Sinica, Marcin Cieslik of University of Michigan, Ann Arbor, and D. R. Mani of the ӳ����ý.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding:</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Support for this research was provided in part by the National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC), a NCI Cancer Center Support Grant, the Next-Generation Pathway of Taiwan Cancer Precision Medicine Program, and the Key and Novel Therapeutics Development Program for Major Diseases at Academia Sinica in Taiwan. </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited:</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Satpathy S et al. <a href="https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00317-4" target="_blank">Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures</a>. <em>Cancer Cell</em>. Online July 31, 2025. DOI: 10.1016/j.ccell.2025.07.011</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/proteomics" hreflang="en">Proteomics Platform</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/proteomics-0" hreflang="en">Proteomics</a></div> <div class="field__item"><a href="/broad-tags/mass-spectrometry" hreflang="en">Mass Spectrometry</a></div> </div> </div> </div> </div> </div> Thu, 31 Jul 2025 15:55:57 +0000 Corie Lok 5559226 at /news/qa-single-cell-and-spatial-proteomics-reveal-proteins-nuanced-roles-health-and-disease <span class="field field--name-title field--type-string field--label-hidden"><h1>Study finds biomarkers, drug targets, risk factors for most common form of lung cancer</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-07-31T11:55:57-04:00" class="datetime">July 31, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Study finds biomarkers, drug targets, risk factors for most common form of lung cancer</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Large analysis of genes and proteins in lung adenocarcinoma points to possible new diagnostic and treatment approaches, and also reveals signatures of chemical exposures in patients who have never smoked.</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Corie Lok </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-07-31T11:55:57-04:00" title="Thursday, July 31, 2025 - 11:55" class="datetime">July 31, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=GWP1xbZ_ 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=GWP1xbZ_ 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=gxIH7wLh 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=wmeltl3H 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=Q-hfwefI 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=5fL08Wv9 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/nci-vol-10578-72.jpg?h=436b82d4&itok=5fL08Wv9" alt="Microscopy image of lung cancer cells shown in bright colors (blue and green)" title="Microscopy image of lung cancer cells shown in bright colors (blue and green)" typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: National Cancer Institute \ Winship Cancer Institute of Emory University </div> <div class="media-caption__description"> Lung cancer cells, tagged with fluorescent proteins (green and blue), seen under a microscope. </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div 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field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/lung-cancer-proteome-builds-genetic-findings-reveal-therapeutic-strategies" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/lung-cancer-proteome-builds-genetic-findings-reveal-therapeutic-strategies"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=XCehabb4 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=XCehabb4 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=iEAZOtvA 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=iEAZOtvA 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=Fr-ibLwn 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="285" height="186"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=0762cRLO 1x" media="all and (max-width: 539px)" type="image/jpeg" width="220" height="186"/> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2020/NCI-cancer-1088514-main.jpg?h=d3e04ee7&itok=0762cRLO" alt="Lung cancer cells (Credit: NCI)" title="Lung cancer cells (Credit: NCI)" typeof="foaf:Image" /> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/lung-cancer-proteome-builds-genetic-findings-reveal-therapeutic-strategies" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Lung cancer proteome builds on genetic findings to reveal therapeutic strategies</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/more-complete-molecular-picture-lung-squamous-cell-carcinoma-comes-view" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/more-complete-molecular-picture-lung-squamous-cell-carcinoma-comes-view"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=3SlotK-f 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=3SlotK-f 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="104" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=2PAHGlkS 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=2PAHGlkS 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="87" height="104"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=iq3SuxmI 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="285" height="186"/> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=yCWwum9E 1x" media="all and (max-width: 539px)" type="image/jpeg" width="220" height="186"/> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/news/images/2021/LSCC_EdUthman_Flickr_8695759179_096cd56a04_o_0.jpg?h=d3e04ee7&itok=yCWwum9E" alt="Lung squamous cell carcinoma cells (Credit: <a href="https://flic.kr/p/efq3fp" target="_blank">Ed Uthman/Flickr</a>)" title="Lung squamous cell carcinoma cells (Credit: <a href="https://flic.kr/p/efq3fp" target="_blank">Ed Uthman/Flickr</a>)" typeof="foaf:Image" /> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/more-complete-molecular-picture-lung-squamous-cell-carcinoma-comes-view" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">A more complete molecular picture of lung squamous cell carcinoma comes into view</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never smoked. These factors include a pattern of DNA damage and signatures of exposures to chemicals found in processed foods and cosmetics. The findings could lead to better precision medicine strategies for this most common type of lung cancer. </p> <p>The researchers systematically studied genes and proteins across the whole genome and proteome in lung tumors and paired noncancerous lung tissues from more than 400 patients from North America, Eastern Europe, and Asia, making it the largest “proteogenomic” study of any cancer to date. </p> <p>By creating and studying this detailed molecular portrait of lung adenocarcinoma, the team found: </p> <ul> <li>several candidate biomarkers that could be used to more accurately identify patients with poor prognoses</li> <li>a strong link between poor outcomes and a type of DNA damage in tumors in which the DNA was broken up into many small fragments</li> <li>biological mechanisms underlying a subset of early-stage tumors that behave more like advanced cancers</li> <li>more than two dozen tumor molecules that could potentially be targeted by existing FDA-approved drugs, compounds in clinical trials, or new medicines yet to be developed. </li> </ul> <p>The work, published in <a href="https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00317-4" target="_blank"><em>Cancer Cell</em></a>, was led by scientists from the ӳ����ý, Academia Sinica in Taiwan, the University of Michigan in Ann Arbor, and other institutions, and is the result of an unprecedented collaboration between the <a href="https://dctd.cancer.gov/programs/occpr">National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC)</a> and the <a href="https://icpc.cancer.gov/portal/">International Cancer Proteogenome Consortium (ICPC)</a>, which brings together researchers from more than a dozen countries. </p> <p>Because of this collaboration, the team was able to access a large number of tumor samples and deeply analyze a range of lung cancer risk factors that haven’t been well studied before, such as exposures to chemicals beyond tobacco smoke. </p> <p>“Lung cancer continues to be the leading cancer killer worldwide, and even though we've made progress, it is not a solved problem,” said <a href="/bios/michael-gillette">Michael Gillette</a>, co-senior author of the study and senior group leader and principal investigator in the <a href="/proteomics">Proteomics Platform</a> at the ӳ����ý. “My hope is that by bringing new understanding to the biology of lung adenocarcinoma, proposing some therapeutic strategies and new ways to identify high-risk patients, and also by providing an important resource for researchers, our work will lay the groundwork for better ways to diagnose and treat this deadly cancer.”</p> <p>“Large-scale collaborations such as this one enable access to genetically and geographically varied sample sets, making this study more truly reflective of the diversity of lung adenocarcinoma," said Shankha Satpathy, co-first author of the study and a senior group leader and principal investigator in the ӳ����ý’s Proteomics Platform when the study was conducted.</p> <h2>Lung cancer atlas</h2> <p>Despite new targeted therapies for lung cancer over the last two decades, lung adenocarcinoma still kills the majority of patients, including many who have never smoked, suggesting the need for a deeper look at the disease. </p> <p>In their study, the researchers found that patients who had tumors with DNA that was shattered into many small pieces had worse prognoses. The scientists pinpointed a potential biomarker, a protein called IGF2BP3, whose levels correlated with the intensity of this genome fragmentation. The team said this candidate biomarker could potentially be used to identify patients with increased risk of severe disease.</p> <p>Because of the study’s large sample size, the scientists were able to delve into the effects of carcinogens such as tobacco smoke, air pollutants, and chemicals called nitrosamines found in processed food and cosmetics. The researchers looked for molecular signatures associated with smoking and nitrosamine exposures, and found that patients who had the strongest nitrosamine signatures were mostly never-smokers who nevertheless fared as poorly as those who had smoked. </p> <p>This surprising finding suggests that nitrosamines may be an important contributor to lung cancer risk in people who have never smoked. The team created a panel of biomarker candidates that could potentially provide prognostic signals for the disease in people with high chemical exposures. </p> <p>The scientists also learned more about a recently discovered subgroup of lung adenocarcinoma, where patients have tumors that look like early-stage disease according to conventional measures but have molecular characteristics and outcomes of late-stage cancer. The researchers revealed new details about the underlying biology fueling this “early-stage, late-like” form and suggested that these patients might benefit from closer monitoring and more intensive treatment.</p> <p>Gillette said the study shows the power of international collaboration and large-scale genomic and proteomic analysis of cancer, which may pave the way toward better clinical care. </p> <p>“The way we do prognostication now is based on clinical measures and how tumor biopsies look under a microscope,” said Gillette. “But if we can move towards using molecular signatures from tumors to determine cancer prognosis, we could do a better job of finding those early-stage cancers that will turn aggressive and treating those patients earlier and more effectively to save more lives.”    </p> <p>  <br> <em>The other first authors of the study are Natalie Clark of the ӳ����ý, Yi-Ju Chen of Academia Sinica in Taiwan, Noshad Hosseini and Yi Hsiao of University of Michigan in Ann Arbor, Ya-Hsuan Chang of National Health Research Institutes in Taiwan, Jonathan Lei of Baylor College of Medicine in Houston, Texas, Francesca Petralia of Icahn School of Medicine at Mount Sinai in New York, and Jin-Shing Chen of National Taiwan University Hospital and National Taiwan University College of Medicine. </em></p> <p><em>The study’s other senior authors are Yu-Ju Chen of Academia Sinica, Marcin Cieslik of University of Michigan, Ann Arbor, and D. R. Mani of the ӳ����ý.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding:</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Support for this research was provided in part by the National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC), a NCI Cancer Center Support Grant, the Next-Generation Pathway of Taiwan Cancer Precision Medicine Program, and the Key and Novel Therapeutics Development Program for Major Diseases at Academia Sinica in Taiwan. </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited:</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Satpathy S et al. <a href="https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00317-4" target="_blank">Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures</a>. <em>Cancer Cell</em>. Online July 31, 2025. DOI: 10.1016/j.ccell.2025.07.011</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/proteomics" hreflang="en">Proteomics Platform</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/proteomics-0" hreflang="en">Proteomics</a></div> <div class="field__item"><a href="/broad-tags/mass-spectrometry" hreflang="en">Mass Spectrometry</a></div> </div> </div> </div> </div> </div> Thu, 05 Sep 2024 14:40:19 +0000 arinavetta 5557271 at