/ en Tue, 11 Mar 25 14:40:51 -0400 /stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Tue, 11 Mar 2025 18:40:51 +0000 szawalic 5558346 at /news/largest-ever-genetic-study-epilepsy-finds-possible-therapeutic-targets <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 03 Oct 2024 09:03:18 +0000 arinavetta 5557166 at /news/machine-learning-approach-helps-researchers-design-better-gene-delivery-vehicles-gene-therapy <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Wed, 07 Aug 2024 17:00:00 +0000 adicorat 5557196 at /news/qa-how-stem-cell-bank-helping-scientists-understand-psychiatric-disorders <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 25 Jul 2024 14:00:00 +0000 adicorat 5557146 at /news/brain-chimeroids-offer-window-relationships-between-genetics-and-exposures <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Mon, 08 Jul 2024 14:30:38 +0000 tulrich@broadinstitute.org 5557106 at /news/schizophrenia-and-aging-may-share-common-biological-basis <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Wed, 06 Mar 2024 16:00:00 +0000 adicorat 5556511 at /news/whyiscience-qa-software-engineer-develops-computational-tools-psychiatric-and-brain-research <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Wed, 21 Feb 2024 15:00:00 +0000 chenders@broadinstitute.org 5556501 at /news/qa-how-jump-start-new-psychiatric-and-neurological-drug-development <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Mon, 18 Dec 2023 15:02:23 +0000 tulrich@broadinstitute.org 5556201 at /news/scientists-map-locations-hundreds-thousands-cell-types-across-mammalian-brain <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; vertical-align:top; padding-right:10px; text-align:right; font-family:Open Sans, sans-serif; font-weight: 600!important; line-height: normal!important; float:left; font-size:90%; width:35%; //display:inline; } .speakerdet { //width:65%; padding-bottom: 40px!important; margin-top: -5px; text-transform:none!important; float:left; } .ttitle { font-family: Open Sans, sans-serif;font-weight: 600!important;line-height: normal!important;vertical-align:top;text-transform:none!important;margin-top:3px; } .blue { color:#006db6; } .speaker { font-weight:400!important; margin-top:20px; line-height:normal; } .speaker a:link { font-weight:400!important; } .nomargintop { margin-top:1px!important; } .affil, .affil a:link { font-weight:400!important; line-height:normal; font-size:90%;width:100%;float:left; } //.affil a:link { //font-weight:400; //line-height:1.2 !important; //font-size:100%; //} .panel-pane.pane-node-field-gsp-images { margin-bottom:0px; margin-top:0px; } .pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" target="_blank">Register</a>.</p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Wed, 13 Dec 2023 16:00:00 +0000 leah@broadinstitute.org 5556186 at /news/schizophrenia-gene-mutation-causes-many-changes-mouse-brain <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Samantha Zawalich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-03-11T14:40:51-04:00" title="Tuesday, March 11, 2025 - 14:40" class="datetime">March 11, 2025</time> </span> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodesection-pagebreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics">Symposium</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodesection-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Severe Mental Illness: From Genes to Mechanisms to Therapeutics</h1> </span> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodesection-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This two-day in-person symposium on September 16 and 17, 2025, will be chaired by Dr. Steve Hyman, director of the Program in Brain Health at Ó³»­´«Ã½, Dr. Kris Dickson of the Stanley Center at Ó³»­´«Ã½, Dr. Zhanyan Fu of the Stanley Center at Ó³»­´«Ã½, Dr. Evan Macosko of the Stanley Center at the Ó³»­´«Ã½ and Harvard Medical School, and Dr. Elise Robinson of Massachusetts General Hospital and associate director of Human Genetics at the Stanley Center. It will bring together scientists working on the frontiers of genetics, neurobiology, computational psychiatry, and therapeutic development for schizophrenia, bipolar disorder, and related neuropsychiatric disorders.</p> <p>The central theme of this symposium revolves around addressing the challenges of turning human genetics findings for severe mental illnesses into biology that will inform and drive the identification of biomarkers and novel therapeutics. In this symposium, speakers will present important new findings that will have an impact on neuropsychiatric research. The program will include keynote speeches from David Altshuler, EVP and CSO of Vertex and Belinda Lennox, Head of the Department of Psychiatry, University of Oxford along with a wide range of other talks, panels, and a poster session.</p> <p>Register at <a href="http://broad.io/stanleysymposium">http://broad.io/stanleysymposium</a>.</p> <p> </p> <p><a id="day1" name="day1"></a></p> <p> </p> <h2>Agenda</h2> <div class="speaker">Chairs: <a href="/node/1281836">Kris Dickson</a>, <a href="/node/5453">Zhanyan Fu</a>, <a href="/node/7576">Steve Hyman</a>, <a href="/node/652411">Evan Macosko</a>, <a href="/node/6847">Elise Robinson</a></div> <p> </p> <h3>Day 1: Tuesday, September 16, 2025</h3> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day2">View day 2</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Opening Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Welcome</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 1</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:05 - 10:05 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="/node/7601">David Altshuler</a></div> <div class="affil">Vertex</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 1: Psychiatric genetics and genomics: Progress and challenges</div> <div class="speaker"><a href="/node/6847" target="_blank">Chair: Elise Robinson</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:05 - 10:35 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/7003" target="_blank">Ben Neale</a></div> <div class="affil">MGH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:35 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:50 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/6847" target="_blank">Elise Robinson </a></div> <div class="affil">HSPH & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:20 - 11:50 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://www.med.upenn.edu/gandallab/" target="_blank">Mike Gandal</a></div> <div class="affil">University of Pennsylvania</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:50 - 12:20 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="/node/113841" target="_blank">Jason Buenrostro </a></div> <div class="affil">Harvard University & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:20 - 1:20 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 2: Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery</div> <div class="speaker"><a href="/node/5453" target="_blank">Chair: Zhanyan Fu</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:20 - 1:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/5453">Zhanyan Fu</a></div> <div class="affil">Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:30 - 2:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://gradschool.weill.cornell.edu/faculty/conor-liston" target="_blank">Conor Liston</a></div> <div class="affil">Cornell University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:00 - 2:30 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman </a></div> <div class="affil">MIT & Whitehead Institute</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:30 - 3:00 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop" style="padding-top:0;"><a href="https://med.stanford.edu/kauer-lab.html" target="_blank">Julie Kauer </a></div> <div class="affil">Stanford</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:00 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">3:15 - 3:40 pm</div> <div class="speakerdet"> <div class="ttitle blue">Poster Session previews</div> <div class="speaker">TBD</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:40 - 4:50 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion on genetic medicine – addressing quantitative gene defects</div> <div class="speaker"><a href="/node/652411" target="_blank">Moderator: Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="/node/7012">Guoping Feng</a><br> MIT & Ó³»­´«Ã½</li> <li><a href="https://www.voyagertherapeutics.com/about-leadership/" target="_blank">Toby Ferguson </a><br> Voyager</li> <li><a href="https://www.sfari.org/people/kelsey-c-martin/" target="_blank">Kelsey Martin</a><br> SFARI</li> <li><a href="https://wi.mit.edu/people/member/weissman" target="_blank">Jonathan Weissman</a><br> MIT & Whitehead Institute</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">4:50 - 5:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue"><a id="day2" name="day2"></a>Stanley Center Poster Session</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">5:00 - 7:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Reception and poster session</div> </div> </div> </td> </tr> </tbody> </table> <div style="clear:both;"> </div> <h3>Day 2: Wednesday, September 17, 2025</h3> <div> <div style="display:none;"> <div class="sesstime"> </div> <div class="sesstime" style="float:right;"><a href="#day1">View day 1</a></div> </div> <table class="contenttbl"> <tbody> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:00 - 8:45 am</div> <div class="speakerdet"> <div class="ttitle blue">Breakfast</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Keynote 2</div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:45 - 8:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote Introduction</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">8:55 - 9:55 am</div> <div class="speakerdet"> <div class="ttitle blue">Keynote</div> <div class="speaker"><a href="https://www.psych.ox.ac.uk/team/belinda-lennox" target="_blank">Belinda Lennox</a></div> <div class="affil">Oxford University</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 3: Understanding mental illness mechanisms using human model systems and clinical cohorts</div> <div class="speaker"><a href="/node/652411" target="_blank">Chair: Evan Macosko</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">9:55 - 10:00 am</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="/node/652411" target="_blank">Evan Macosko </a></div> <div class="affil">HMS & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:00 - 10:30 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://researchportal.helsinki.fi/en/persons/olli-pekka-herman-pietil%C3%A4inen" target="_blank">Olli Pietiläinen</a></div> <div class="affil">University of Helsinki & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">10:30 - 11:00 am</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">TALK_TITLE</div> <div class="speaker nomargintop"><a href="https://beardenlab.semel.ucla.edu/" target="_blank">Carrie Bearden</a></div> <div class="affil">UCLA</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">11:00 - 11:20 am</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> <div> <div class="sesstime">11:20 - 12:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Fireside Chat</div> <div class="speaker"><a href="https://www.lisagenova.com/" target="_blank">Lisa Genova </a>with <a href="/node/7576">Steve Hyman</a></div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="sesstime">12:00 - 1:00 pm</div> <div class="speakerdet"> <div class="ttitle blue">Lunch</div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div class="ttitle blue">Session 4: Frontiers of mechanistic and therapeutic discovery in the central nervous system</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Chair: Randy Buckner</a></div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:00 - 1:05 pm</div> <div class="speakerdet"> <div class="ttitle blue">Session Introduction</div> <div class="speaker"><a href="https://bucknerlab.fas.harvard.edu/" target="_blank">Randy Buckner</a></div> <div class="affil">Harvard University </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:05 - 1:35 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="https://labs.icahn.mssm.edu/roussos-lab/" target="_blank">Panos Roussos</a></div> <div class="affil">Mount Sinai</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">1:35 - 2:05 pm</div> <div class="speakerdet"> <div class="ttitle blue" style="display:none;">Deep learning approaches to antibiotic discovery</div> <div class="speaker nomargintop"><a href="/node/515316">Morgan Sheng</a></div> <div class="affil">MIT & Ó³»­´«Ã½</div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div> <div class="sesstime">2:05 - 2:25 pm</div> <div class="speakerdet"> <div class="ttitle blue">Coffee Break</div> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">2:25 - 3:15 pm</div> <div class="speakerdet"> <div class="ttitle blue">Panel discussion – What do we need to get industry re-engaged?</div> <div class="speaker"><a href="/node/7576" target="_blank">Moderator: Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"> <ul> <li><a href="https://www.linkedin.com/in/james-cronican-1662b45/" target="_blank">James Cronican</a><br> Boehringer Ingelheim</li> <li><a aria-label="Fiona Ellwood - open in a new tab" href="https://innovativemedicine.jnj.com/fiona-elwood-phd" target="_blank">Fiona Elwood</a><br> J&J</li> <li><a href="https://www.linkedin.com/in/ross-jeggo-5745a411/" target="_blank" uw-rm-external-link-id="https://www.biogen.com/company/leadership/grogan-jane.html$janegrogan">Ross Jeggo</a><br> Biogen</li> <li><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a><br> Seaport Therapeutics</li> </ul> </div> </div> </div> </td> </tr> <tr> <td colspan="2" style="vertical-align:top;"> <div> <div class="sesstime">3:15 - 3:30 pm</div> <div class="speakerdet"> <div class="ttitle blue">Closing Remarks</div> <div class="speaker"><a href="/node/7576" target="_blank">Steve Hyman</a></div> <div class="affil">Harvard & Ó³»­´«Ã½</div> <div class="speaker"><a href="https://seaporttx.com/team/" target="_blank">Steve Paul</a></div> <div class="affil">Seaport Therapeutics</div> </div> </div> </td> </tr> </tbody> </table> </div> <style type="text/css">.contenttbl { width:100%!important; line-height:normal!important; text-transform:none!important; } .sesstime { white-space: nowrap; 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.pane-node-field-gsp-featured-description { margin-bottom:0px; margin-top:0px; } @media only screen and (min-width:321px) and (max-width:580px) { .contenttbl { width:100%;} .speakerdet { padding-bottom:30px; } .sesstime { text-align:left; width:100%!important; padding-bottom:10px; } </style></div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics" class="node node--type-section-page node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodesection-pagefield-gsp-extra-info"> <div class="clearfix text-formatted field field--name-field-gsp-extra-info field--type-text-long field--label-hidden field__item"><p><a class="transparent-orange-button" href="http://broad.io/stanleysymposium" 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