Golub Lab / en Mon, 19 Sep 22 10:53:09 -0400 ӳý Discovery Center in Cambridge opens to the public this October /news/broad-discovery-center-cambridge-opens-public-october <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Mon, 19 Sep 2022 14:53:09 +0000 kzusi@broadinstitute.org 1195701 at Researchers find genetic “Achilles heel” in ovarian and uterine cancers /news/researchers-find-genetic-%E2%80%9Cachilles-heel%E2%80%9D-ovarian-and-uterine-cancers <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Tue, 19 Apr 2022 13:40:12 +0000 adicorat 1130876 at Scientists discover a new kind of cell death linked to copper /news/scientists-discover-new-kind-cell-death-linked-copper <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Thu, 17 Mar 2022 13:41:33 +0000 Corie Lok 1127881 at Count Me In opens to all patients with cancer across the United States and Canada /news/count-me-opens-all-patients-cancer-across-united-states-and-canada <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Sat, 21 Aug 2021 16:05:00 +0000 kzusi@broadinstitute.org 1053911 at CRISPR enzyme can boost growth of cells with cancer mutations /news/crispr-enzyme-can-boost-growth-cells-cancer-mutations <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Mon, 18 May 2020 04:00:00 +0000 Corie Lok 629736 at Personalized blood biopsies demonstrate potential as early-warning signal of breast cancer recurrence /news/personalized-blood-biopsies-demonstrate-potential-early-warning-signal-breast-cancer-recurrence <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Fri, 13 Mar 2020 14:09:26 +0000 kzusi@broadinstitute.org 627566 at Expanding the reach of proteasome inhibitors /news/expanding-reach-proteasome-inhibitors <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Tue, 28 May 2019 14:55:21 +0000 tulrich@broadinstitute.org 533821 at Cancer cell lines evolve in ways that affect how they respond to drugs /news/cancer-cell-lines-evolve-ways-affect-how-they-respond-drugs <span class="field field--name-title field--type-string field--label-hidden">CTD^2 Dashboard</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The CTD<sup>2</sup> Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD<sup>2</sup>) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD<sup>2</sup> Dashboard as a web interface that compiles Network-generated summaries about key cancer biology findings and cancer-relevant results related to genes, proteins, and compounds. Dashboard submissions are ranked with a system of validation tiers to indicate strength of evidence.</p> <p> <strong>Publications</strong></p> <p> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29220450" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/29220450</a></p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Maria Nemchuk</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2017-05-04T11:44:53-04:00" title="Thursday, May 4, 2017 - 11:44" class="datetime">May 4, 2017</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://ctd2-dashboard.nci.nih.gov/dashboard/">CTD^2 Dashboard</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">Portals</div> <div class="field__item">Cancer</div> <div class="field__item">cell line profiling</div> <div class="field__item">small molecules</div> <div class="field__item">Therapeutic Response</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">ӳý tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/paul-clemons" hreflang="en">Paul Clemons</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> </div> </div> Wed, 08 Aug 2018 17:10:21 +0000 tulrich@broadinstitute.org 326366 at