Zhang Lab / en Wed, 17 Dec 25 11:00:59 -0500 New study suggests a way to rejuvenate the immune system /news/new-study-suggests-way-rejuvenate-immune-system <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Wed, 17 Dec 2025 16:00:59 +0000 Corie Lok 5559931 at Cas9 ancestor engineered into a compact genome editing tool /news/cas9-ancestor-engineered-compact-genome-editing-tool <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Wed, 14 May 2025 20:46:34 +0000 tulrich@broadinstitute.org 5558701 at Researchers uncover new CRISPR-like system in animals that can edit the human genome /news/researchers-uncover-new-CRISPR-like-system-in-animals-that-can-edit-the-human-genome <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Wed, 28 Jun 2023 15:00:11 +0000 leah@broadinstitute.org 1282401 at Ó³»­´«Ã½ Discovery Center in Cambridge opens to the public this October /news/broad-discovery-center-cambridge-opens-public-october <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Mon, 19 Sep 2022 14:53:09 +0000 kzusi@broadinstitute.org 1195701 at New programmable gene editing proteins found outside of CRISPR systems /news/new-programmable-gene-editing-proteins-found-outside-crispr-systems <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Thu, 09 Sep 2021 23:14:59 +0000 kzusi@broadinstitute.org 1090166 at Scientists harness human protein to deliver molecular medicines to cells /news/scientists-harness-human-protein-deliver-molecular-medicines-cells <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Thu, 19 Aug 2021 18:00:00 +0000 adicorat 1050296 at Rapid test for COVID-19 shows improved sensitivity /news/rapid-test-covid-19-shows-improved-sensitivity <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Thu, 17 Sep 2020 15:55:58 +0000 kzusi@broadinstitute.org 653721 at SHERLOCK-based one-step test provides rapid and sensitive COVID-19 detection /news/sherlock-based-one-step-test-provides-rapid-and-sensitive-covid-19-detection <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Tue, 05 May 2020 12:07:14 +0000 kzusi@broadinstitute.org 628541 at How the Ó³»­´«Ã½ is helping understand and overcome COVID-19 /news/how-broad-institute-helping-understand-and-overcome-covid-19 <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Wed, 22 Apr 2020 15:20:16 +0000 Corie Lok 627646 at A chemical approach to imaging cells from the inside /news/chemical-approach-imaging-cells-inside <span class="field field--name-title field--type-string field--label-hidden">Ó³»­´«Ã½-Novartis Cancer Cell Line Encyclopedia (CCLE)</span> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p> The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.</p> <p> <span style="display:none;">cell line profiling</span></p> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By bistline@broadinstitute.org</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2012-02-16T15:36:59-05:00" title="Thursday, February 16, 2012 - 15:36" class="datetime">February 16, 2012</time> </span> <div class="field field--name-field-software-link field--type-link field--label-above"> <div class="field__label">Link</div> <div class="field__items"> <div class="field__item"><a href="https://portals.broadinstitute.org/ccle/home">CCLE</a></div> </div> </div> <div class="field field--name-field-taxonomy-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__items"> <div class="field__item">cell lines</div> <div class="field__item">CCLE</div> <div class="field__item">cancer portals</div> <div class="field__item">cancer models</div> <div class="field__item">Cancer</div> <div class="field__item">cancer dependency</div> <div class="field__item">dependency map</div> <div class="field__item">cell line profiling</div> </div> </div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-above"> <div class="field__label">Ó³»­´«Ã½ tags</div> <div class="field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> </div> </div> Thu, 20 Jun 2019 15:55:38 +0000 kzusi@broadinstitute.org 549266 at