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        3. Publications A catalog of scientific papers published by our members and staff scientists.
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      1. Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.
      2. Gerstner Center for Cancer Diagnostics The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.
      3. Klarman Cell Observatory The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.
      4. Merkin Institute for Transformative Technologies in Healthcare The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.
      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Ó³»­´«Ã½ and the Danish research community.
      6. Eric and Wendy Schmidt Center The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.
      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
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      1. Art and science connection Explore the connection between art and science and how we bring together artists and Ó³»­´«Ã½ scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
      2. Ó³»­´«Ã½ Discovery Center Visit our free public educational space that showcases how researchers at the Ó³»­´«Ã½ and their colleagues around the world seek to understand and treat human disease.
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Strong Genes: Insights Into Polygenic Risk and Coronary Artery Calcium in Older Individuals.
Patel AP. Strong Genes: Insights Into Polygenic Risk and Coronary Artery Calcium in Older Individuals. Circulation. Cardiovascular imaging. 2024:e017531. doi:10.1161/CIRCIMAGING.124.017531
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Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy.
Curran L, de Marvao A, Inglese P, et al. Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy. Circulation. Genomic and precision medicine. 2023;16(6):e004200. doi:10.1161/CIRCGEN.123.004200
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Rapid evolution of a skin-lightening allele in southern African KhoeSan.
Lin M, Siford RL, Martin AR, et al. Rapid evolution of a skin-lightening allele in southern African KhoeSan. Proc Natl Acad Sci U S A. 2018;115(52):13324-13329. doi:10.1073/pnas.1801948115
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The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes.
Almeda-Valdes P, Velasco DVG, Campos OA, et al. The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes. Eur J Endocrinol. 2019;180(2):99-107. doi:10.1530/EJE-18-0677
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Estimating cross-population genetic correlations of causal effect sizes.
Galinsky KJ, Reshef YA, Finucane HK, et al. Estimating cross-population genetic correlations of causal effect sizes. Genet Epidemiol. 2019;43(2):180-188. doi:10.1002/gepi.22173
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Discovery of common and rare genetic risk variants for colorectal cancer.
Huyghe JR, Bien SA, Harrison TA, et al. Discovery of common and rare genetic risk variants for colorectal cancer. Nat Genet. 2019;51(1):76-87. doi:10.1038/s41588-018-0286-6
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Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.
Wang H, Cade BE, Sofer T, et al. Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans. Hum Mol Genet. 2019;28(4):675-687. doi:10.1093/hmg/ddy387
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Quantification of somatic mutation flow across individual cell division events by lineage sequencing.
Brody Y, Kimmerling RJ, Maruvka YE, et al. Quantification of somatic mutation flow across individual cell division events by lineage sequencing. Genome Res. 2018;28(12):1901-1918. doi:10.1101/gr.238543.118
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Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort.
Galván-Femenía I, Obón-Santacana M, Piñeyro D, et al. Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. J Med Genet. 2018;55(11):765-778. doi:10.1136/jmedgenet-2018-105437
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MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease.
Juge PA, Lee JS, Ebstein E, et al. MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease. N Engl J Med. 2018;379(23):2209-2219. doi:10.1056/NEJMoa1801562
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In March of 2020, Ó³»­´«Ã½ converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Ó³»­´«Ã½ Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Ó³»­´«Ã½'s Scientists in the Classroom program, Ó³»­´«Ã½ researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Ó³»­´«Ã½ working side-by-side with mentors on cutting-edge research.

In November 2022, Ó³»­´«Ã½â€™s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Ó³»­´«Ã½â€™s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Ó³»­´«Ã½ has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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