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Rajat Gupta is an associate member at the Ó³»­´«Ã½ of MIT and Harvard and an associate professor of medicine at Harvard Medical School with a research laboratory in the Divisions of Cardiovascular Medicine and Genetics at Brigham and Women’s Hospital (BWH). Gupta's lab leverages human genetics and functional genomics to discover and validate new therapeutic targets for vascular diseases, with a particular focus on coronary artery disease (CAD). A major contribution to the field involves pioneering the use of single-cell RNA sequencing to characterize the heterogeneity of endothelial cells and large-scale CRISPR perturbation studies to map the causal gene regulatory networks that drive vascular disease risk. This work has successfully linked common genetic risk pathways for CAD to genes involved in rare cerebrovascular diseases. As a cardiologist, Gupta directs the vascular disease genetics program and sees patients in the Center for Cardiovascular Genetics at BWH, focusing on rare vascular disorders such as Marfan Syndrome, genetic aortopathies, and other vascular malformations.

Gupta graduated from the University of Pennsylvania School of Medicine where he was awarded the Adolf J. Creskoff Prize. He completed internal medicine residency training at Massachusetts General Hospital, cardiology fellowship at Brigham and Women’s Hospital, and a post-doctoral fellowship in Human Genetics at the Ó³»­´«Ã½. His research is funded by grants from the NIH (NIH Director’s New Innovator Award, 2019), the National Heart, Lung, and Blood Institute, the Ó³»­´«Ã½, the Sperling Family Fellowship, and the Chan Zuckerberg Initiative.