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Genetic screens point to VPS4A and VPS4B as promising cancer drug targets

The Metastasis Map can help researchers learn what causes some tumors to disseminate to different organs.

Study probes interplay of genetics, ancestry, and environment in cancer risk

Ó³»­´«Ã½ scientists are using brain, kidney, and tumor organoids to gain new insights into disease mechanisms and therapeutic approaches.

Findings offer a roadmap for how to build compounds to target proteins for degradation by the cell’s recycling system.

Cancer cells that have lost a copy of a critical gene may be vulnerable to therapies that knock out the remaining copy

Cas9 can cut DNA without any guide RNA and select for cells with inactivated p53.

Study reveals that ancestry-associated features are found in hundreds of genes, and are closely tied to specific tissues

Single-cell RNA sequencing maps immune microenvironment changes that arise before myeloma appears, and reveals opportunities for developing personalized treatments.

Study suggests chemotherapy itself can cause gliomas to mutate more, and that mutation burden alone is not enough to rouse the immune system against them.