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New arrhythmia risk factors, a genetic switch in advanced prostate cancer, and massive-scale drug combination screening at the bench.

By probing genetic variation, scientists continue to unearth the roots of disease and pave the way for precision medicine.

Building on multiple genome-wide association studies, researchers identify a distant regulator of the EDN1 gene that influences risk for five vascular disorders.

New work points to inflammation as key player in heart disease; suggests future potential for screening to reduce risk

The study of structural variation — large-scale changes in DNA that can, in some cases, refashion entire chromosomes — in the genomic era has lagged behind that of sequence variation. But there’s a growing appreciation of how important structural variants are to human biology and disease. What makes these variants more challenging to study, and what is being done to overcome those challenges?

Genetics can predict some of your risk for heart disease, but lifestyle is important, too. A new study of 55,000 people found that favorable lifestyle habits can offset some of a person's genetic risk, reducing coronary events by half among those at high genetic risk.