Chemical Biology and Therapeutics Science Program

Using multiplex-cytological (MC) and gene-expression (GE) profiling assays, we assembled a reference dataset of profiles for structurally and stereochemically diverse diversity-oriented synthesis (DOS)-derived compounds (18,000-20,000), chemically diverse Molecular Libraries Program (MLP) compounds with biologically diverse performance identified...

Chemical Biology and Therapeutics Science

About

The Chemical Biology and Therapeutics Science (CBTS) Program at the Ó³»­´«Ã½ brings together a talented group of researchers with a variety of backgrounds, all of whom share a deep commitment to advancing biology and medicine through the use of chemistry and related molecular approaches. Recent advances have expanded the scope of chemical biology and therapeutics science to include: 

Screens of the Ó³»­´«Ã½â€™s entire DOS (Diversity Oriented Synthesis) library of over 100,000 small molecules on the malaria parasite P. falciparum have identified compounds that act on a novel malaria target during all three stages of the disease.
News 09.07.2016
Chemistry-based approach reveals new target in fight against malaria

After screening a library of over 100,000 small molecules, researchers from the Ó³»­´«Ã½ of MIT and Harvard have identified compounds that act on a novel target in the malaria parasite, Plasmodium falciparum. resulted in the publication of a paper (available online September 7 inNature] and an open, data-rich resource for the malaria research community called the(MTRP).

Chemical Biology and Therapeutics Science Program
Schreiber Lab
Infectious Disease and Microbiome
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The Cancer Therapeutics Response Portal (CTRP) links genetic, lineage, and other cellular features of cancer cell lines to small-molecule sensitivity with the goal of accelerating discovery of patient-matched cancer therapeutics. CTRP can be mined to develop insights into small-molecule mechanisms of action and novel therapeutic hypotheses, and...