Identifying and Targeting Cancer Dependencies with Small Molecules
Using multiplex-cytological (MC) and gene-expression (GE) profiling assays, we assembled a reference dataset of profiles for structurally and stereochemically diverse diversity-oriented synthesis (DOS)-derived compounds (18,000-20,000), chemically diverse Molecular Libraries Program (MLP) compounds with biologically diverse performance identified...
The Cancer Therapeutics Response Portal (CTRP) links genetic, lineage, and other cellular features of cancer cell lines to small-molecule sensitivity with the goal of accelerating discovery of patient-matched cancer therapeutics. CTRP can be mined to develop insights into small-molecule mechanisms of action and novel therapeutic hypotheses, and...