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Small-molecule-sensitivity profiling of cancer cell lines (CCLs) has emerged as an approach to illuminate the mechanism of action of compounds and to launch the early stage of the discovery of new precision therapies. In a study in , a team of scientists from ӳ����ý's  — led by researchers Stuart Schreiber, Paul Clemons, and Alykhan Shamji — presents the largest CCL sensitivity dataset to date, and an exciting new analysis method, termed “annotated cluster multi-dimensional enrichment” (ACME), integrating information from multiple CCLs and small molecules.