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Genetic disorders are often hard to model. This is particularly true for those caused by non-allelic homologous recombinations (NAHR) — which occur when highly similar portions of the genome wrongly recombine. A new study from Ó³»­´«Ã½ associate members James Gusella and Michael Talkowski, both of Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), and first author Derek J.C. Tai, also of MGH and HMS, describes a new method for using the genome engineering tool CRISPR/Cas-9 that accurately models NAHR abnormalities. Find out more about this new approach and what it means for the study of genetic disorders in .