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Chemical probes — small molecules that interact with a protein’s function — can be powerful tools to reveal the roles of targeted proteins in health and disease, but probes are sometimes of low quality, and high-quality ones can be misused. , a multi-institutional team, including Ó³»­´«Ã½â€™s Stuart Schreiber, Nathanael Gray, and Joanne Kotz, describe plans for a new community-driven wiki-like site, called the , that crowdsources medicinal chemistry and pharmacology expertise to catalog the best chemical probes for a given protein target. The resource aims to support research in basic biology and the pursuit of new therapeutics.