Ó³»­´«Ã½

Of the more than 80 million known genetic variants, few are well understood for their roles in human health and disease. To overcome this gap in knowledge, large consortia studies need to share data across traditional boundaries — a hard task when there are few standards in place to harmonize those data. In a special report in the , Ó³»­´«Ã½ institute member and Clinical Research Sequencing Platform (CRSP) clinical director Heidi Rehm and colleagues describe the NIH-funded ClinGen program, which aims to be an authoritative central resource for defining the clinical relevance of genomic variants for use in precision medicine and research. wrote about the report, which was among a set of papers published by the journal that addressed the promises and .