New method characterizes amplification bias in single-cell genomic DNA
By Ó³»´«Ã½ Communications
In , a team led by researchers from the Ó³»´«Ã½, MIT, and Dana-Farber Cancer Center describes new statistical methods that account for artifacts introduced by whole-genome amplification of single-cell genomic DNA. Their approach establishes a system for characterizing amplification bias and provides a framework for quality assurance in single-cell DNA libraries. Ó³»´«Ã½ associate member J. Christopher Love and institute member Matthew Meyerson were senior authors of the study; Ó³»´«Ã½ researchers Cheng-Zhong Zhang and Viktor Adalsteinsson were first authors.