Researchers describe chemical screen for small molecules that overcome stroma-induced drug resistance in multiple myeloma cells
By Ó³»´«Ã½ Communications
Overcoming mechanisms of drug resistance is an ongoing obstacle in developing successful cancer therapeutics. , researchers from the Ó³»´«Ã½'s Center for the Development of Therapeutics and colleagues describe using multiple myeloma-stroma cell co-cultures to screen for small molecules that overcome stroma-induced drug resistance; notably, they identified a compound that uniquely interacts with a microtubule-bound mitotic protein highly expressed in multiple myeloma cells compared with normal blood cells. These finding illustrate how chemical biology can complement genetics to advance therapeutics discovery.