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Whole-exome sequencing—a technique that decodes the genetic information in protein-coding genes—has transformed the understanding and analysis of cancer biology, but the impact of this revolutionary technique has yet to reach patients in the clinic.

What: Glioblastoma, the most common and most aggressive form of brain cancer in adults, remains effectively incurable. Evidence suggests that “stem-like” cells help drive this difficult-to-treat disease. These cells may possess properties that give them the ability to resist treatment and drive cancer’s growth, but pinpointing them and understanding the circuitry that makes them behave the way they do has been a major challenge.