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Cancer

Deep learning guided design of protease substrates.

Martin-Alonso C, Alamdari S, Samad TS, Yang KK, Bhatia SN, Amini AP. Deep learning guided design of protease substrates. Nature communications. 2026;17(1):54. doi:10.1038/s41467-025-67226-1

Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity.

Pimenta EM, Garza AE, Camp SY, et al. Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity. Science translational medicine. 2026;18(833):eadw4689. doi:10.1126/scitranslmed.adw4689

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS.

van Tienen LM, Bayoumi S, Muneeruddin K, et al. Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS. Cell chemical biology. 2026. doi:10.1016/j.chembiol.2026.01.007

Comparative genomics reveals LINE-1 recombination with diverse RNAs.

Law CT, Burns KH. Comparative genomics reveals LINE-1 recombination with diverse RNAs. Cell genomics. 2026:101165. doi:10.1016/j.xgen.2026.101165

MYC amplification and MYC protein expression are poor prognostic markers in pediatric and young adult osteosarcoma.

Nagy MR, Puopolo O, Alston E, et al. MYC amplification and MYC protein expression are poor prognostic markers in pediatric and young adult osteosarcoma. Cancer. 2025;131(22):e70161. doi:10.1002/cncr.70161

Scaling computational genomics to millions of individuals with GPUs.

Taylor-Weiner A, Aguet F, Haradhvala NJ, et al. Scaling computational genomics to millions of individuals with GPUs. Genome Biol. 2019;20(1):228. doi:10.1186/s13059-019-1836-7

A nuclease-polymerase chain reaction enables amplification of probes used for capture-based DNA target enrichment.

Leong KW, Yu F, Adalsteinsson VA, et al. A nuclease-polymerase chain reaction enables amplification of probes used for capture-based DNA target enrichment. Nucleic Acids Res. 2019. doi:10.1093/nar/gkz870

Passenger Hotspot Mutations in Cancer.

Hess JM, Bernards A, Kim J, et al. Passenger Hotspot Mutations in Cancer. Cancer Cell. 2019;36(3):288-301.e14. doi:10.1016/j.ccell.2019.08.002

Finding the edge of the seat.

Van Allen EM. Finding the edge of the seat. Nat Med. 2019;25(9):1328. doi:10.1038/s41591-019-0557-5

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Parikh AR, Leshchiner I, Elagina L, et al. Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019;25(9):1415-1421. doi:10.1038/s41591-019-0561-9