Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments.
ACS Comb Sci
| Authors | |
| Abstract | Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1-5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM). |
| Year of Publication | 2016
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| Journal | ACS Comb Sci
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| Volume | 18
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| Issue | 9
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| Pages | 569-74
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| Date Published | 2016 Sep 12
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| ISSN | 2156-8944
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| DOI | 10.1021/acscombsci.6b00050
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| PubMed ID | 27518324
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| PubMed Central ID | PMC5022782
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