When Small Molecules Are Like Real Estate: It's All about Location, Location, Location.
Cell Chem Biol
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| Abstract | In this issue of Cell Chemical Biology, Park et al. (2018) demonstrate that targeting apoptazole, an Hsp70 inhibitor, to mitochondria induces apoptosis by a distinct mechanism of action different from unmodified apoptazole, which accumulates in the lysosome. These results highlight the power of subcellular localization in small-molecule selectivity. |
| Year of Publication | 2018
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| Journal | Cell Chem Biol
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| Volume | 25
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| Issue | 10
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| Pages | 1169-1170
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| Date Published | 2018 Oct 18
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| ISSN | 2451-9448
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| DOI | 10.1016/j.chembiol.2018.10.004
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| PubMed ID | 30339956
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