The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
| Authors | |
| Abstract | To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation. |
| Year of Publication | 2016
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| Journal | Nat Genet
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| Volume | 48
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| Issue | 10
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| Pages | 1171-84
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| Date Published | 2016 Oct
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| ISSN | 1546-1718
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| DOI | 10.1038/ng.3667
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| PubMed ID | 27618452
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| PubMed Central ID | PMC5042863
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| Links | |
| Grant list | R01 HL086694 / HL / NHLBI NIH HHS / United States
MR/L01341X/1 / Medical Research Council / United Kingdom
R01 AG025941 / AG / NIA NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 HL113933 / HL / NHLBI NIH HHS / United States
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