Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing.

Clin Infect Dis
Authors
Anne Piantadosi
Sanjat Kanjilal
Vijay Ganesh
Arjun Khanna
Emily Hyle
Jonathan Rosand
Tyler Bold
Hayden Metsky
Jacob Lemieux
Michael Leone
Lisa Freimark
Christian Matranga
Gordon Adams
Graham McGrath
Siavash Zamirpour
Sam Telford
Eric Rosenberg
Tracey Cho
Matthew Frosch
Marcia Goldberg
Shibani Mukerji
Pardis Sabeti
Keywords
Humans
Male
Middle Aged
Metagenomics
Genome, Viral
Immunologic Factors
Encephalitis Viruses, Tick-Borne
Encephalitis, Tick-Borne
Immunoglobulins, Intravenous
Abstract

We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.
Year of Publication
2018
Journal
Clin Infect Dis
Volume
66
Issue
5
Pages
789-792
Date Published
2018 02 10
ISSN
1537-6591
DOI
10.1093/cid/cix792
PubMed ID
29020227
PubMed Central ID
PMC5850433
Links
Grant list
KL2 TR001100 / TR / NCATS NIH HHS / United States
T32 AG000222 / AG / NIA NIH HHS / United States
T32 AI007061 / AI / NIAID NIH HHS / United States
HHMI / Howard Hughes Medical Institute / United States

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