Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.

Nat Genet

Authors	Sklar S Schwab N Williams Daly S Schaffner Maier Albus Trixler Eichhammer B Lerer J Hallmayer Norton Williams Zammit A Cardno Jones G McCarthy Milanova Kirov M O'Donovan E Lander M Owen D Wildenauer
Keywords	Humans Proto-Oncogene Proteins Linkage Disequilibrium Case-Control Studies Polymorphism, Genetic Schizophrenia Genetics, Population Microsatellite Repeats Chromosomes, Human, Pair 6 Receptors, Cell Surface Receptors, Notch Great Britain
Abstract	A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
Year of Publication	2001
Journal	Nat Genet
Volume	28
Issue	2
Pages	126-8
Date Published	2001 Jun
ISSN	1061-4036
DOI	10.1038/88836
PubMed ID	11381257
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