Tracking tumor-specific CD8 T cell responses.
Trends in immunology
| Authors | |
| Abstract | In a recent article, Puig-Saus et al. computationally predict and experimentally validate neoantigen-specific T cell responses in patients with melanoma. They identify a restricted set of neoantigens recognized by polyclonal CD8 T cells as a unique feature of anti-PD-1 responders and engineer autologous tumor-responsive T cells expressing neoantigen-specific TCRs, providing proof-of-concept for future cellular therapies. |
| Year of Publication | 2023
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| Journal | Trends in immunology
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| Volume | 44
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| Issue | 5
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| Pages | 326-328
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| Date Published | 05/2023
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| ISSN | 1471-4981
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| DOI | 10.1016/j.it.2023.03.012
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| PubMed ID | 37031062
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