Astrocytes on steroids binge on synapses to cope with stress.
Immunity
| Authors | |
| Abstract | Many mechanisms by which stress mediates its effects within the central nervous system still remain unknown. Byun, Kim, Kim et al. find that early-life stress triggers corticosterone release to drive astrocyte-dependent synapse elimination and altered behavior. Thus, this work defines a steroid-sensitive astrocyte transcriptional circuit controlling behavior, highlighting how the study of CNS immunoregulation may shed light on behavior. |
| Year of Publication | 2023
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| Journal | Immunity
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| Volume | 56
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| Issue | 9
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| Pages | 1983-1985
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| Date Published | 09/2023
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| ISSN | 1097-4180
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| DOI | 10.1016/j.immuni.2023.08.013
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| PubMed ID | 37703827
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