Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations.

Bioinformatics (Oxford, England)
Authors
Abstract

SUMMARY: Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations.AVAILABILITY AND IMPLEMENTATION: Admix-kit package is open-source and available at . Additionally, users can use the pipeline designed for admixed genotype simulation available at .SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Year of Publication
2024
Journal
Bioinformatics (Oxford, England)
Date Published
03/2024
ISSN
1367-4811
DOI
10.1093/bioinformatics/btae148
PubMed ID
38490256
Links