Force-free activation of Notch with DNA origami.
Trends in genetics : TIG
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| Abstract | The Notch signaling pathway is a highly conserved, fundamental process to embryogenesis and neurogenesis. While force-induced conformational change is known to activate Notch receptors, Smyrlaki et al. recently used DNA origami to reveal an additional, force-independent mode of Notch activation via soluble presentation of spatially controlled ligand nanopatterns. |
| Year of Publication | 2024
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| Journal | Trends in genetics : TIG
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| Date Published | 03/2024
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| ISSN | 0168-9525
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| DOI | 10.1016/j.tig.2024.03.001
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| PubMed ID | 38493041
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