Embryonic microglia maintain the brain's cortical fault lines.
Trends in immunology
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| Abstract | Lawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1. |
| Year of Publication | 2024
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| Journal | Trends in immunology
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| Date Published | 04/2024
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| ISSN | 1471-4981
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| DOI | 10.1016/j.it.2024.04.005
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| PubMed ID | 38664101
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