Velcrin compounds activate the SLFN12 tRNase to induce tomoptosis.
Cell chemical biology
| Authors | |
| Abstract | Velcrins are molecular glues that induce complex formation between PDE3A and SLFN12. The PDE3A-SLFN12 complex activates the SLFN12 RNase, resulting in cleavage of the specific substrate, tRNA-Leu-TAA, global inhibition of translation, and death of cells expressing sufficient levels of both proteins. Here, unanswered questions about the mechanism of action and therapeutic promise of velcrin compounds are discussed. |
| Year of Publication | 2024
|
| Journal | Cell chemical biology
|
| Volume | 31
|
| Issue | 6
|
| Pages | 1039-1043
|
| Date Published | 06/2024
|
| ISSN | 2451-9448
|
| DOI | 10.1016/j.chembiol.2024.05.012
|
| PubMed ID | 38906108
|
| Links |