Breadcrumb Home Publications Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α. The Journal of clinical investigation Authors Hong Wang Maria Miranda Eizo Marutani Paul Lichtenegger Gregory Wojtkiewicz Fumito Ichinose Vamsi Mootha Keywords Genetics Hypoxia Year of Publication 2024 Journal The Journal of clinical investigation Volume 134 Issue 23 Date Published 12/2024 ISSN 1558-8238 DOI 10.1172/JCI185569 PubMed ID 39621311 Links Recent Ó³»´«Ã½ Publications Distinct Spatially Resolved Tumor Microenvironment Trajectories Define Benefit from Ramucirumab plus Pembrolizumab in Refractory PD-L1+ Gastric Cancer. Muscle transcriptome profiling reveals novel molecular pathways and biomarkers in laminin-α2 deficient patients. Circadian Ser107Pro variant bridges difficulty awakening in the morning and adiposity. Learning genetic perturbation effects with variational causal inference. Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning.