Product and trial design considerations on the path towards a vaccine to combat opioid overdose.
NPJ vaccines
| Authors | |
| Abstract | Opioid overdose deaths are an evolving public health emergency in the United States. Recent advancements in drug conjugate vaccine design and adjuvantation technologies have re-ignited interest in the potential clinical utility of opioid vaccination. Here we present the concept of fentanyl vaccination as a complementary strategy for opioid overdose prevention with a focus on vaccine safety, efficacy, and considerations for vaccine development and testing in early phase human clinical trials. |
| Year of Publication | 2025
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| Journal | NPJ vaccines
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| Volume | 10
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| Issue | 1
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| Pages | 35
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| Date Published | 02/2025
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| ISSN | 2059-0105
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| DOI | 10.1038/s41541-025-01083-3
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| PubMed ID | 39971929
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