Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.
| Authors | |
| Abstract | Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (n = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes. |
| Year of Publication | 2025
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| Journal | Nature communications
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| Volume | 16
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| Issue | 1
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| Pages | 3438
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| Date Published | 04/2025
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| ISSN | 2041-1723
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| DOI | 10.1038/s41467-025-58574-z
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| PubMed ID | 40210677
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