Mitigating antimicrobial resistance by innovative solutions in AI (MARISA): a modified James Lind Alliance analysis.

npj antimicrobials and resistance
Authors
Abstract

Antimicrobial resistance (AMR) is a critical global health threat and artificial intelligence (AI) presents new opportunities for our response. However, research priorities at the AI-AMR intersection remain undefined. This study aimed to identify and prioritise key areas for future investigation. Using a modified James Lind Alliance approach, we conducted semi-structured interviews with eight experts in AI and AMR between February and June 2024. Analysis of 338 coded responses revealed 44 distinct themes. Major barriers included fragmented data access, integration challenges and economic disincentives. The top ten priorities identified were: Combination Therapy, Novel Therapeutics, Data Acquisition, AMR Public Health Policy, Prioritisation, Economic Resource Allocation, Diagnostics, Modelling Microbial Evolution, AMR Prediction and Surveillance. A notable limitation was the underrepresentation of data from high-burden regions, limiting the generalisability of findings. To address these gaps, we propose the novel BARDI framework: Brokered Data-sharing, AI-driven Modelling, Rapid Diagnostics, Drug Discovery and Integrated Economic Prevention.

Year of Publication
2025
Journal
npj antimicrobials and resistance
Volume
3
Issue
1
Pages
75
Date Published
09/2025
ISSN
2731-8745
DOI
10.1038/s44259-025-00150-y
PubMed ID
40890455
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