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Functional genomics data, such as chromatin state maps, provide critical insights into biological processes, but are hard to navigate and interpret. We present Epilogos to address this challenge by offering a simple information-theoretic framework for large-scale visualization, navigation and interpretation of functional genomics annotations, and apply it to over 2,000 genome-wide chromatin state maps in human and mouse. We construct intuitive visualizations of multi-tissue chromatin state maps, prioritize salient genomic regions, identify group-wise differential regions, and enable rapid similarity search given a region of interest. To facilitate usability, we provide a purpose-built web-based browser interface () alongside open-source software for community access and adoption.