Lingering Effects: Environmental Exposure Leads to Clonal Hematopoiesis via IL1RAP in 9/11 First Responders.
Cancer discovery
| Authors | |
| Abstract | In this issue, Verma, Zeig-Owens, Goldfarb, and colleagues report that increased prevalence of clonal hematopoiesis (CH) among 9/11 World Trade Center first responders is accompanied by uncharacteristic mutations in younger responders and an elevated risk of blood cancer. Using a mouse model of CH, they connect the clonal expansion triggered by World Trade Center particulate matter exposure to higher levels of IL1RAP, offering a new potential target to limit clonal expansion and reduce CH-associated risks. See related article by Verma et al., p. 2468. |
| Year of Publication | 2025
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| Journal | Cancer discovery
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| Volume | 15
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| Issue | 12
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| Pages | 2406-2407
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| Date Published | 12/2025
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| ISSN | 2159-8290
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| DOI | 10.1158/2159-8290.CD-25-1584
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| PubMed ID | 41327968
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| Links |