Benchmarking Gaussian processes for prediction and data assimilation of Alzheimer's disease progression.

Journal of Alzheimer's disease : JAD
Authors
Keywords
Abstract

The ability to predict the trajectory of disease progression with high resolution for individual patients can enhance clinical trial design, enabling personalized, data-driven medical approaches. In this study, we deployed a kernel/Gaussian process-based dynamic model to predict Alzheimer's disease progression. Our numerical results demonstrate that the dynamic method outperforms static linear regression, improving the prediction of ADAS-Cog 11 subscores over extended periods by effectively incorporating intermediate data observations. This approach highlights the potential of computational models in enhancing clinical trial design and advancing personalized medicine for Alzheimer's disease.

Year of Publication
2025
Journal
Journal of Alzheimer's disease : JAD
Pages
13872877251404082
Date Published
12/2025
ISSN
1875-8908
DOI
10.1177/13872877251404082
PubMed ID
41384838
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