Burned by experience: Epigenetic inflammatory memory in neurons drives synaptopathy after infection.
Neuron
| Authors | |
| Abstract | Shammas et al. report that LCMV infection epigenetically primes hippocampal neurons for heightened responses to viral rechallenge, driving synaptopathy. These findings suggest epigenetic inflammatory memory in neurons, resembling previous observations in other CNS non-immune cells, and may guide therapeutic interventions. |
| Year of Publication | 2026
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| Journal | Neuron
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| Volume | 114
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| Issue | 4
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| Pages | 553-555
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| Date Published | 02/2026
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| ISSN | 1097-4199
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| DOI | 10.1016/j.neuron.2026.01.019
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| PubMed ID | 41713392
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