Testing the mettle of RNA methylation in T cell exhaustion.
The Journal of experimental medicine
| Authors | |
| Abstract | Song et al. () identify Mettl8 as a regulator of progenitor exhausted CD8+ T cells, stabilizing Tcf7 transcripts and shaping chromatin programs. Mettl8 loss drives effector differentiation and improves tumor control, underscoring RNA methylation as a key layer of T cell fate regulation. |
| Year of Publication | 2026
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| Journal | The Journal of experimental medicine
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| Volume | 223
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| Issue | 5
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| Date Published | 05/2026
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| ISSN | 1540-9538
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| DOI | 10.1084/jem.20260349
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| PubMed ID | 42043377
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