Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents.
J Am Chem Soc
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| Abstract | We have developed and applied an approach to reaction discovery that takes advantage of DNA encoding, DNA-programmed assembly of substrate pairs, in vitro selection, and PCR amplification, yet does not require reaction conditions that support DNA hybridization. This system allows the simultaneous evaluation of >200 potential bond-forming combinations of substrates in a single experiment and can be applied in a range of solvent and temperature conditions. In an initial application, we applied this system to explore Au(III)-mediated chemistry and uncovered a simple, mild method for the selective Markovnikov-type hydroarylation of vinyl arenes and trisubstituted olefins with indoles. |
| Year of Publication | 2007
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| Journal | J Am Chem Soc
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| Volume | 129
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| Issue | 48
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| Pages | 14933-8
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| Date Published | 2007 Dec 05
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| ISSN | 1520-5126
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| DOI | 10.1021/ja074155j
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| PubMed ID | 17994738
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| PubMed Central ID | PMC2538361
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| Grant list | R01 GM065865 / GM / NIGMS NIH HHS / United States
R01 GM065865-04 / GM / NIGMS NIH HHS / United States
R01GM065865 / GM / NIGMS NIH HHS / United States
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