Copper-mediated amidation of heterocyclic and aromatic C-H bonds.
Org Lett
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| Abstract | A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs. |
| Year of Publication | 2009
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| Journal | Org Lett
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| Volume | 11
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| Issue | 22
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| Pages | 5178-80
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| Date Published | 2009 Nov 19
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| ISSN | 1523-7052
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| DOI | 10.1021/ol902079g
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| PubMed ID | 19860425
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| PubMed Central ID | PMC2776381
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| Grant list | P01 CA078048 / CA / NCI NIH HHS / United States
P01-CA078048 / CA / NCI NIH HHS / United States
Howard Hughes Medical Institute / United States
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