Macrocycloadditions leading to conformationally restricted small molecules.
Org Lett
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| Abstract | [reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents. |
| Year of Publication | 2006
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| Journal | Org Lett
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| Volume | 8
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| Issue | 10
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| Pages | 2063-6
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| Date Published | 2006 May 11
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| ISSN | 1523-7060
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| DOI | 10.1021/ol0604724
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| PubMed ID | 16671782
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