Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

Curr Opin Chem Biol
Authors
Keywords
Abstract

Reversible acetylation of lysines on the amino-terminal tails of nucleosomal histones is correlated with changes in chromatin structure and transcription. The recent characterization of enzymes directly responsible for regulating histone acetylation and deacetylation and the cloning of their encoding cDNAs have provided insights into the possible functional and regulatory mechanisms of these classes of molecules. Nuclear histone acetylases have been shown to be transcriptional coactivators and coactivator-associated proteins, while histone deacetylases have been identified as components of nuclear co-repressor complexes. These findings confirm previous studies linking histone acetylation and transcriptional regulation.

Year of Publication
1997
Journal
Curr Opin Chem Biol
Volume
1
Issue
3
Pages
300-8
Date Published
1997 Oct
ISSN
1367-5931
PubMed ID
9667866
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