ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.

Beilstein J Org Chem

Authors	Willmen Youngsaye Cathy Hartland Barbara Morgan Amal Ting Partha Nag Benjamin Vincent Carrie Mosher Joshua Bittker Sivaraman Dandapani Michelle Palmer Luke Whitesell Susan Lindquist Stuart Schreiber Benito Munoz
Abstract	The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure-activity relationships led to the discovery of ML212.
Year of Publication	2013
Journal	Beilstein J Org Chem
Volume	9
Pages	1501-7
Date Published	2013
ISSN	1860-5397
DOI	10.3762/bjoc.9.171
PubMed ID	23946849
PubMed Central ID	PMC3740683
Links
Grant list	R03 MH086456 / MH / NIMH NIH HHS / United States U54 HG005032 / HG / NHGRI NIH HHS / United States