Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.
J Am Chem Soc
| Authors | |
| Keywords | |
| Abstract | Introducing a silyl group at one of the internal olefin positions in diolefinic substrates results in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this method to a range of macrocyclic (E)-alkenylsiloxanes is described. Protodesilylation of alkenylsiloxane products yields novel Z-configured macrocycles. |
| Year of Publication | 2011
|
| Journal | J Am Chem Soc
|
| Volume | 133
|
| Issue | 24
|
| Pages | 9196-9
|
| Date Published | 2011 Jun 22
|
| ISSN | 1520-5126
|
| DOI | 10.1021/ja202012s
|
| PubMed ID | 21557625
|
| Links | |
| Grant list | P50 GM069721 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States
|